{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:52:58Z","timestamp":1782856378058,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":76,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015310","name":"Natural Science Foundation of Xinjiang","doi-asserted-by":"publisher","award":["2019D01C153"],"award-info":[{"award-number":["2019D01C153"]}],"id":[{"id":"10.13039\/501100015310","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hypertension"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    The aim of this study was to explore the association of serum anti\u2010lysosomal\u2010associated membrane protein\u20102 (anti\u2010LAMP\u20102) antibody with vasculitis combined with hypertension (VAS\u2010HTN). A total of 51 VAS\u2010HTN patients, 46 essential hypertension (EH) patients, and 46 healthy controls (HC) were included in the study. Serum anti\u2010LAMP\u20102 antibody levels are increased in VAS\u2010HTN patients as compared with EH and HC (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Serum anti\u2010LAMP\u20102 antibody levels were significantly higher in active stage patients than those in non\u2010active stage patients and HC (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). The correlation analysis showed a significant positive correlation between serum anti\u2010LAMP\u20102 antibody levels and the Birmingham Vasculitis Activity Score (BVAS) and hypersensitive C\u2010reactive protein (Hs\u2010CRP) (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Among the subsets of VAS\u2010HTN, the levels of serum anti\u2010LAMP\u20102 antibody were remarkably higher in all VAS\u2010HTN subsets compared with HC (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). More interestingly, the levels of serum anti\u2010LAMP\u20102 antibody were remarkably increased in polyarteritis nodosa (PAN) patients compared with ANCA\u2010associated vasculitis and Takayasu arteritis patients (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). In addition, there was a significant positive correlation between serum anti\u2010LAMP\u20102 antibody levels and BAVS and Hs\u2010CRP in PAN patients (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Multivariate logistic regression analysis showed that the anti\u2010LAMP\u20102 antibody was independently associated with VAS\u2010HTN. The levels of serum anti\u2010LAMP\u20102 antibody were remarkably increased in VAS\u2010HTN patients compared to EH and HC and might reflect the disease activity. The anti\u2010LAMP\u20102 antibody may be a potential biomarker for diagnosis and estimating the disease activity in VAS\u2010HTN.\n                  <\/jats:p>","DOI":"10.1155\/2022\/9656560","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T16:35:25Z","timestamp":1647621325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Association of Serum Anti\u2010Lysosomal\u2010Associated Membrane Protein\u20102 Antibody with Vasculitis Combined with 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