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However, the potential mechanism underlying the role of ferroptosis in asthma remains unclear. In this study, we established the mouse asthma model following the ovalbumin (OVA) method in C57BL\/6 mice and the cell model with IL\u201013 induction in bronchial epithelial cells (BEAS\u20102B cells). Treatment of ferrostatin\u20101 (Ferr\u20101) and 3\u2010methyladenine (3\u2010MA) decreased iron deposition in IL\u201013\u2010induced BEAS\u20102B cells and lung tissues of asthma mice, opposite to that in bronchoalveolar lavage fluid (BALF). Meanwhile, excessive lipid peroxidation asthma model <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> was alleviated by Ferr\u20101 or 3\u2010MA treatment. In addition, Ferr\u20101 and 3\u2010MA inhibited the expression of LC\u20103 in these cells and lung tissues of mice. Moreover, Ferr\u20101 and 3\u2010MA also suppressed the production of inflammatory cytokines (IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, and TNF\u2010<jats:italic>\u03b1<\/jats:italic>) and oxidative stress factors (ROS and MDA), while promoting the level of SOD, <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Furthermore, application of Ferr\u20101 exhibited a greater inhibitory effect on iron release and lipid peroxidation in IL\u201013\u2010induced BEAS\u20102B cells and asthma mice than 3\u2010MA, accompanied with a weaker effect on ferritinophagy than 3\u2010MA. Collectively, Ferr\u20101 and 3\u2010MA ameliorated asthma <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> through inhibiting ferroptosis, providing a new strategy for the clinical treatment of asthma.<\/jats:p>","DOI":"10.1155\/2022\/9657933","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T00:05:13Z","timestamp":1644019513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Ferrostatin\u20101 and 3\u2010Methyladenine Ameliorate Ferroptosis in OVA\u2010Induced Asthma Model and in IL\u201013\u2010Challenged BEAS\u20102B 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