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Fibroblast growth factor 19 (FGF19) is a well\u2010known intestine\u2010derived inhibitor of bile acid biosynthesis. However, it is largely unknown about the roles of FGF19 in improving sepsis\u2010associated metabolic disorder and organ injury. In the present study, mice were intravenously injected recombinant human FGF19 daily for 7 days followed by lipopolysaccharide (LPS) administration. At 24 hours after LPS stimuli, sera were collected for metabolomic analysis. Ingenuity pathway analysis (IPA) network based on differential metabolites (DMs) was conducted. Here, metabolomic analysis revealed that FGF19 pretreatment reversed the increase of LPS\u2010induced fatty acids. IPA network indicated that altered linoleic acid (LA) and gamma\u2010linolenic acid (GLA) were involved in the regulation of oxidative stress and mitochondrial function and were closely related to reactive oxygen species (ROS) generation. Further investigation proved that FGF19 pretreatment decreased serum malondialdehyde (MDA) levels and increased serum catalase (CAT) levels. In livers, FGF19 suppressed the expression of inducible NO synthase (iNOS) and enhanced the expression of nuclear factor erythroid 2\u2010related factor 2 (NRF2) and hemeoxygenase\u20101 (HO\u20101). Finally, FGF19 pretreatment protected mice against LPS\u2010induced liver, ileum, and kidney injury. Taken together, FGF19 alleviates LPS\u2010induced organ injury associated with improved serum LA and GLA levels and oxidative stress, suggesting that FGF19 might be a promising target for metabolic therapy for sepsis.<\/jats:p>","DOI":"10.1155\/2022\/9673512","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T05:35:10Z","timestamp":1657172110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fibroblast Growth Factor 19 Improves LPS\u2010Induced Lipid Disorder and Organ Injury by Regulating Metabolomic Characteristics in 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