{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:15:24Z","timestamp":1773717324863,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Changzhou Health Young Cultivation Project","award":["CZQM2020101"],"award-info":[{"award-number":["CZQM2020101"]}]},{"name":"Changzhou Health Young Cultivation Project","award":["PMTCT201904"],"award-info":[{"award-number":["PMTCT201904"]}]},{"name":"China Association for the Prevention and Control of STDs and AIDS\u00b7 AbbVie Fund for Maternal and Child Care and Prevention of Mother-to-Child Transmission","award":["CZQM2020101"],"award-info":[{"award-number":["CZQM2020101"]}]},{"name":"China Association for the Prevention and Control of STDs and AIDS\u00b7 AbbVie Fund for Maternal and Child Care and Prevention of Mother-to-Child Transmission","award":["PMTCT201904"],"award-info":[{"award-number":["PMTCT201904"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2022,9,5]]},"abstract":"<jats:p>Background. Although the prevention of mother-to-child transmission of syphilis program in China has achieved national coverage for 7 years, controversy still exists regarding the treatment of syphilis and the serological significance of syphilis. Objective. To explore the occurrence and influencing factors of adverse pregnancy outcomes among pregnant women with syphilis in Changzhou from 2015-2019 and to further analyze the impact of syphilis serologic titers on perinatal outcomes and neonatal serologic outcomes. Methods. Syphilis-infected pregnant women reported in Changzhou City from 2015 to 2019 were selected as the study population (data were obtained from the \u201cChina Information System for Prevention of Mother-to-child Transmission of AIDS, Syphilis and Hepatitis B.\u201d Demographic characteristics, laboratory tests, and medication were collected to describe adverse pregnancy outcomes and the distribution of non-pale leptospiral antibody titers during pregnancy. Multivariate logistic regression was used to analyze the factors influencing adverse pregnancy outcomes. We also compared differences in syphilis titers among mothers who received different interventions, differences in serologic outcomes of their children, and correlations between them. Results. For mothers with syphilis infection, we found no treatment during pregnancy (OR\u2009=1.70) and an initial titer greater than 1\u2009:\u20098 (OR\u2009=2.28) to be risk factors. For treated pregnant women, increasing age (OR\u2009=1.08), lack of standardized treatment (OR\u2009=1.87), and initial titer greater than 1\u2009:\u20098 (OR\u2009=1.69) were risk factors, while previous parity was a protective factor (OR\u2009=0.62). For untreated pregnant women, marital status (OR\u2009=2.40) and initial titers greater than 1\u2009:\u20098 (OR\u2009=3.57) were risk factors. There were statistically significant differences (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.01<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) in serologic titer changes, time to antibody regression, and time to exclusion of syphilis infection in children of pregnant women with syphilis infection after receiving different interventions during pregnancy, but different time distributions of interventions had no effect on these three indicators. Conclusion. Pregnant women with syphilis should actively cooperate with their doctors in the standardized treatment of pregnancy, and doctors should also pay more attention to pregnant women with syphilis whose initial titers are greater than 1\u2009:\u20098. High-quality prenatal care is a key component in interrupting mother-to-child transmission of syphilis and preventing various adverse pregnancy outcomes. The adaptation of standardized treatment protocols for pregnant women with syphilis in China is a strong proof of the progress of precision medicine.<\/jats:p>","DOI":"10.1155\/2022\/9673850","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T23:20:26Z","timestamp":1662420026000},"page":"1-12","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of Adverse Pregnancy Outcomes of Pregnant Women with Syphilis and Maternal-Infant Serological Association in Changzhou, China, 2015\u20132019"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-8306","authenticated-orcid":true,"given":"Chaorong","family":"Bian","sequence":"first","affiliation":[{"name":"Changzhou Children\u2019s Hospital Affiliated to Nantong University, Changzhou, 226019 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Qin","sequence":"additional","affiliation":[{"name":"Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, 215123 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengtao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, 215123 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manman","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, 215123 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6958-9955","authenticated-orcid":true,"given":"Kejin","family":"Chen","sequence":"additional","affiliation":[{"name":"Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213000 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00837-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.12.107623"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.01.010"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211720"},{"key":"5","volume-title":"Training course on prevention of mother-to-child transmission of AIDS, syphilis and hepatitis B","author":"J. Xi","year":"2016"},{"key":"6","first-page":"122","article-title":"Advances in pathogenesis of syphilis serofast state","volume":"2","author":"Z. Yu-lei","year":"2014","journal-title":"Journal of Practical Dermatology"},{"issue":"4","key":"7","first-page":"199","article-title":"Research progress of related mechanisms of sero-resistance in syphilis","volume":"6","author":"L. Yuanquan","year":"2018","journal-title":"Chinese Journal of Clinical Laboratory Management (Electronic Edition)"},{"issue":"12","key":"8","first-page":"1226","article-title":"Epidemiologic characteristics and adverse pregnancy outcomes of material syphilis in Jiangsu provision, 2013-2016","volume":"24","author":"L. I. Lin","year":"2018","journal-title":"Chinese Journal of AIDS & STD"},{"key":"9","first-page":"1284","article-title":"Analysis of adverse pregnancy outcomes and related factors in pregnant women with syphilis infection in Guangxi of China, 2014-2018","volume":"12","author":"Q. Qinghua","year":"2019","journal-title":"Chinese Journal of Preventive Medicine"},{"issue":"8","key":"10","first-page":"558","article-title":"Adverse pregnancy outcomes among women with syphilis in Zhejiang province, 2013- 2014","volume":"49","author":"Z. Xiaohui","year":"2016","journal-title":"Chinese Journal of Dermatology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-03314-y"},{"key":"12","article-title":"Notice of the General Office of the National Health and Family Planning Commission on Comprehensively Carrying out the Prevention of Mother-to-Child Transmission of AIDS, Syphilis and Hepatitis B","year":"2015"},{"issue":"4","key":"13","first-page":"353","article-title":"Syphilis and pregnancy: Study of 85 cases in French Guyana","volume":"37","author":"G. Carles","year":"2008","journal-title":"Journal de Gynecologie, Obstetrique et Biologie de la Reproduction"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102203"},{"issue":"7","key":"15","first-page":"524","article-title":"An analysis status of HIV, syphilis and HBV testing service among pregnant women in some areas of Guangxi in 2009-2013","volume":"20","author":"Y. Hui","year":"2014","journal-title":"Chinese Journal of AIDS & STD"},{"issue":"2","key":"16","first-page":"158","article-title":"Expert consensus on the diagnosis and management of syphilis in pregnancy","volume":"47","author":"Infectious Diseases Collaborative Group of Chinese Medical Association Obstetrics and Gynecology Branch","year":"2012","journal-title":"Chinese Journal of Obstetrics and Gynecology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20203332"},{"issue":"3","key":"18","first-page":"363","article-title":"Analysis on impact of clinical intervention for syphilis in pregnant on pregnancy outcome","volume":"10","author":"Z. Junqin","year":"2016","journal-title":"Chinese Journal of Experimental And Clinical Infectious Diseases"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03740-6"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1080\/02646838.2019.1579897"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13424"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2019.v109i9.13817"},{"key":"23","article-title":"Notice of the General Office of the National Health Commission on Printing and Distributing the Work Norms for the Prevention of Mother-to-Child Transmission of AIDS, Syphilis and Hepatitis B (2020 Edition)","year":"2020"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1097\/FM9.0000000000000018"}],"updated-by":[{"DOI":"10.1155\/2023\/9879658","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"record-id":"49851"},{"DOI":"10.1155\/2023\/9879658","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000}}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2022\/9673850.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2022\/9673850.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2022\/9673850.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T23:20:47Z","timestamp":1662420047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/sci\/2022\/9673850\/"}},"subtitle":[],"editor":[{"given":"Muhammad","family":"Muddassir Ali","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":24,"alternative-id":["9673850","9673850"],"URL":"https:\/\/doi.org\/10.1155\/2022\/9673850","relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9879658","asserted-by":"object"}]},"ISSN":["1687-9678","1687-966X"],"issn-type":[{"value":"1687-9678","type":"electronic"},{"value":"1687-966X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,5]]}}}