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Previous studies indicated the neuroprotective effect of sevoflurane postconditioning (SP) in cerebral IRI. However, the mechanisms still remain elusive. Cerebral IRI models with SP were established by using HSR with C57BL\/6 mice (male, 3\u2010month\u2010old) <jats:italic>in vivo<\/jats:italic> and by using oxygen glucose deprivation and reoxygenation (OGD\/R) with HT22 cells <jats:italic>in vitro<\/jats:italic>. Postoperative cognition was evaluated by the Morris water maze, novel object recognition, and elevated plus maze tests. The role of SIRT1 was determined by using siRNA, a sensitive inhibitor (EX527), or an overexpression shRNA\u2010GFP lentivirus. IRI caused significant disabilities of spatial learning and memory associated with enhanced cerebral infarct and neuronal apoptosis, which were effectively attenuated by SP. IRI also made a significant decrease of SIRT1 accompanied by oxidative stress, mitochondria dysfunction, and inactivated autophagy. SP or genetically overexpressing SIRT1 significantly suppressed defective autophagy, mitochondrial oxidative injury, and neuronal death caused by HSR or OGD\/R. However, genetic suppression or pharmacological inhibition of SIRT1 significantly reversed the impact of SP treatment on mitochondrial DNA transcription ability and autophagy. Our results demonstrate that the loss of SIRT1 causes a sequential chain of mitochondrial dysfunction, defective autophagy, and neuronal apoptosis after IRI in the preclinical stroke models. Sevoflurane postconditioning treatment could effectively attenuate pathophysiological signatures induced by noxious stimuli, which maybe mediated by SIRT1.<\/jats:p>","DOI":"10.1155\/2022\/9771743","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T22:35:10Z","timestamp":1647038110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sevoflurane Improves Hemorrhagic Shock and Resuscitation\u2010Induced Cognitive Impairments and Mitochondrial Dysfunctions through SIRT1\u2010Mediated 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