{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:07:02Z","timestamp":1767168422164,"version":"build-2238731810"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,7,4]]},"abstract":"<jats:p>\n                    Objective. To investigate the correlation between serum total serum bilirubin (TSB) levels and globus pallidus-related metabolic indexes of proton magnetic resonance spectroscopy (1H-MRS) in the newborn with neonatal jaundice. Methods. 50 children with neonatal jaundice admitted to our hospital from January 2019 to January 2021 were recruited and assigned to a mild condition group (TSB\u2009&lt;\u2009221\u2009\u03bcmol\/L, n\u2009=\u200916), a moderate condition group (221\u2009\u03bcmol\/L\u2009\u2264\u2009TSB\u2009&lt;\u20093 42\u2009\u03bcmol\/L, n\u2009=\u200918), and a severe condition group (342\u2009\u03bcmol\/L\u2009\u2264\u2009TSB\u2009&lt;\u2009428\u2009\u03bcmol\/L, n\u2009=\u200916) based on peak TSB. The differences in globus pallidus-related metabolic indexes of 1H-MRS between the groups were compared and their correlation with TSB levels was analyzed. Results. The three groups had comparable N-acetylaspartic acid (NAA)\/creatine (Cr), choline (Cho)\/Cr, lactic acid (Lac)\/Cr, and ml\/Cr levels (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ), while there were statistical differences in glutamine (Glx)\/Cr levels (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). The severe condition group showed the highest levels of neuron-specific enolase (NSE), creatine kinase-MB (CK-MB), and troponin (cTnl), followed by the moderate group, and then the mild group (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). The TSB level is positively correlated with the 1H-MRS metabolic index Glx\/Cr. Conclusions. The serum TSB level is correlated with the 1H-MRS metabolic index Glx\/Cr in the newborn with neonatal jaundice, and the levels of TSB and Glx\/Cr provide a reference for the diagnosis of bilirubin encephalopathy.\n                  <\/jats:p>","DOI":"10.1155\/2022\/9785584","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T14:05:12Z","timestamp":1656943512000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Correlation Analysis of TSB Level and Globus Pallidus-Related Metabolite Indexes of Proton Magnetic Resonance Spectroscopy in the Newborn with Neonatal Jaundice"],"prefix":"10.1155","volume":"2022","author":[{"given":"Chaoyan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Imaging, Hengshui People\u2019s Hospital, Hengshui, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Imaging, Hengshui People\u2019s Hospital, Hengshui, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Imaging, Hengshui People\u2019s Hospital, Hengshui, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Newborn, Hengshui People\u2019s Hospital, Hengshui, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-4542","authenticated-orcid":true,"given":"Zhilei","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Imaging, Hengshui People\u2019s Hospital, Hengshui, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"7\/12","key":"1","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1080\/14767058.2018.1521796","article-title":"Birthplace is a risk factor for exchange transfusion in outborn infants admitted for jaundice in myanmar: a case-control study","volume":"33","author":"F. 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