{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:42:58Z","timestamp":1774928578963,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Project of NHC Key Laboratory of Drug Addiction Medicine","award":["2020DAMOP-0014"],"award-info":[{"award-number":["2020DAMOP-0014"]}]},{"name":"Open Project of NHC Key Laboratory of Drug Addiction Medicine","award":["LJS-201810C"],"award-info":[{"award-number":["LJS-201810C"]}]},{"name":"Open Project of NHC Key Laboratory of Drug Addiction Medicine","award":["2018FE001(-160)"],"award-info":[{"award-number":["2018FE001(-160)"]}]},{"name":"Intestinal Barrier Research Special Fund of Academician Jieshou Li","award":["2020DAMOP-0014"],"award-info":[{"award-number":["2020DAMOP-0014"]}]},{"name":"Intestinal Barrier Research Special Fund of Academician Jieshou Li","award":["LJS-201810C"],"award-info":[{"award-number":["LJS-201810C"]}]},{"name":"Intestinal Barrier Research Special Fund of Academician Jieshou Li","award":["2018FE001(-160)"],"award-info":[{"award-number":["2018FE001(-160)"]}]},{"name":"Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Special Project on Applied Basic Research","award":["2020DAMOP-0014"],"award-info":[{"award-number":["2020DAMOP-0014"]}]},{"name":"Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Special Project on Applied Basic Research","award":["LJS-201810C"],"award-info":[{"award-number":["LJS-201810C"]}]},{"name":"Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Special Project on Applied Basic Research","award":["2018FE001(-160)"],"award-info":[{"award-number":["2018FE001(-160)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,7,30]]},"abstract":"<jats:p>Objectives. Intestinal epithelial barrier function is an important mechanical barrier to maintain intestinal homeostasis and resist the invasion of intestinal pathogens and microorganisms. However, intestinal epithelial barrier function is vulnerable to damage under intestinal ischemia\u2013reperfusion (I\/R) injury. Under a category of pathophysiological conditions, including I\/R, autophagy plays a crucial role. This study is aimed at discussing the role of autophagy inhibitors and activators in intestinal epithelial barrier function after intestinal I\/R by changing autophagy levels. Methods. Mice with intestinal IR underwent 45 minutes of surgery for superior mesenteric artery occlusion. The autophagy inhibitor 3-MA and the autophagy inducer rapamycin (RAP) were used to change the level of autophagy, and then, the expressions of tight junction proteins and intestinal barrier function were detected. Results. The results showed that the autophagy inhibitor 3-MA aggravated intestinal epithelial barrier dysfunction, while the autophagy inducer RAP attenuated intestinal epithelial barrier dysfunction. In addition, promoting autophagy may promote occludin expression by inhibiting claudin-2 expression. Conclusion. Upregulation of autophagy levels by autophagy inducers can enhance intestinal epithelial barrier function after intestinal I\/R.<\/jats:p>","DOI":"10.1155\/2022\/9822157","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T00:05:14Z","timestamp":1659225914000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["Role of Autophagy Inducers and Inhibitors in Intestinal Barrier Injury Induced by Intestinal Ischemia\u2013Reperfusion (I\/R)"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yuejin","family":"Li","sequence":"first","affiliation":[{"name":"Department of General Surgery, The First People\u2019s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032 Yunnan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First 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