{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:48:35Z","timestamp":1787500115807,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2022,4,29]]},"abstract":"<jats:p>Perampanel is a noncompetitive, \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptor antagonist. Herein, we report a case of increased perampanel plasma concentration and impaired consciousness triggered by an infection. The patient had refractory epilepsy associated with hemimegalencephaly. During adolescence, perampanel (maximum dose, 10\u2009mg, oral), valproic acid, clobazam, and lacosamide were administered for seizure control. He was admitted to our hospital with high fever, impaired consciousness, and elevated perampanel plasma level (from 1,300 to 1,790\u2009ng\/mL), but with no increase in the concentration of other antiseizure medications. Further examinations (blood, cerebrospinal fluid, brain magnetic resonance images, and electroencephalogram) revealed no physical cause for impaired consciousness. After discontinuation of perampanel, his level of consciousness gradually improved. The pharmacokinetics of perampanel may be modified by both hemimegalencephaly and infection, resulting in an elevated plasma concentration of perampanel. This case underlines the importance of monitoring perampanel plasma concentration in patients with underlying brain disease who develop an infection.<\/jats:p>","DOI":"10.1155\/2022\/9844820","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T17:20:13Z","timestamp":1651252813000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Infection-Induced Elevated Plasma Perampanel in a Patient with Hemimegalencephaly"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-2501","authenticated-orcid":true,"given":"Yuya","family":"Kinoshita","sequence":"first","affiliation":[{"name":"National Hospital Organization Kumamoto Saishun Medical Center, Department of Pediatrics, Koshi, Japan"},{"name":"Kumamoto University Hospital, Department of Pediatrics, Kumamoto City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-3291","authenticated-orcid":true,"given":"Hiroe","family":"Ueno","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kumamoto Saishun Medical Center, Department of Pediatrics, Koshi, Japan"},{"name":"Kumamoto Takumadai Rehabilitation Hospital, Department of Pediatrics, Kumamoto City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Kurata","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kumamoto Saishun Medical Center, Department of Pediatrics, Koshi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizuru","family":"Ikeda","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kumamoto Saishun Medical Center, Department of Pediatrics, Koshi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Hori","sequence":"additional","affiliation":[{"name":"Aso Medical Center, Department of Pediatrics, Aso City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Okada","sequence":"additional","affiliation":[{"name":"Kumamoto Kenhoku Hospital, Department of Pediatrics, Tamana City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Shimazu","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kumamoto Saishun Medical Center, Department of Pediatrics, Koshi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Fujii","sequence":"additional","affiliation":[{"name":"Arao Municipal Hospital, Department of Pediatrics, Arao City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Matsukura","sequence":"additional","affiliation":[{"name":"Kumamoto-Ashikita Center for The Severely Disabled, Department of Pediatrics, Ashikita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoseki","family":"Imamura","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kumamoto Saishun Medical Center, Department of Pediatrics, Koshi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12865"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12874"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1310\/hpj4804-321"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2018.07.002"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2017.1422743"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2013.0598"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.5234\/cnpt.11.45"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s154388"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.9740\/mhc.2015.01.008"},{"key":"11","first-page":"683","article-title":"Perampanel (Fycompa) A review of clinical efficacy and safety in epilepsy","volume":"41","author":"J. 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