{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:30:38Z","timestamp":1753885838990,"version":"3.41.2"},"reference-count":90,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":74,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007531","name":"Southern Taiwan Science Park","doi-asserted-by":"publisher","award":["BX-03-04-04-110"],"award-info":[{"award-number":["BX-03-04-04-110"]}],"id":[{"id":"10.13039\/501100007531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["KSVGH110-099"],"award-info":[{"award-number":["KSVGH110-099"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Segmental bony defects of the mandible constitute a complete loss of the regional part of the mandible. Although several types of customized three\u2010dimension\u2010printed mandible prostheses (CMPs) have been developed, this technique has yet to be widely used. We used CMP with a pressure\u2010reducing device (PRD) to investigate its clinical applicability. First, we used the finite element analysis (FEA). We designed four models of CMP (P1 to P4), and the result showed that CMP with posterior PRD deployment (P4 group) had the maximum total deformation in the protrusion and right excursion positions, and in clenching and left excursion positions, posterior screws had the minimum von Mises stress. Second, the P4 CMP\u2010PRD was produced using LaserCUSING from titanium alloy (Ti\u20106Al\u20104V). The fracture test result revealed that the maximum static pressure that could be withstood was 189\u2009N, and a fatigue test was conducted for 5,000,000 cycles. Third, animal study was conducted on five male 4\u2010month\u2010old Lanyu pigs. Four animals completed the experiment. Two animals had CMP exposure in the oral cavity, but there was no significant inflammation, and one animal had a rear wing fracture. According to a CT scan, the lingual cortex of the mandible crawled along the CMP surface, and a bony front\u2010to\u2010back connection was noted in one animal. A histological examination indicated that CMP was significantly less reactive than control materials (<jats:italic>p<\/jats:italic> = 0.0170). Adequate PRD deployment in CMP may solve a challenge associated with CMP, thus promoting its use in clinical practice.<\/jats:p>","DOI":"10.1155\/2022\/9880454","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T23:37:14Z","timestamp":1647473834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Customized Three\u2010Dimensionally Printed Mandible Prostheses with a Pressure\u2010Reducing Device: A Finite Element Analysis in Different Chewing Positions, Biomechanical Testing, and In Vivo Animal Study Using Lanyu Pigs"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9222-1550","authenticated-orcid":false,"given":"Chun-Feng","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7993-9760","authenticated-orcid":false,"given":"Chun-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-7863","authenticated-orcid":false,"given":"Han-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Chung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Chih","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Ho","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Lung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Ho","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2017.01.006"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-015-0031-3"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199910000-00011"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004119"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(99)80058-7"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2016.02.020"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-016-0585-y"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-016-0093-x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2008.03.002"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.05.023"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2002.29817"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2003.06.011"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2009.04.011"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2009.07.005"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2011.601279"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2015.08.006"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11548-015-1193-2"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2016.03.015"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.10.015"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2013.10.019"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2019.45.5.276"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2018.12.026"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-020-00272-5"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2016.02.031"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2018.01830"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.07.011"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.013"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.103758"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2017.12.003"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2013.10.011"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000005228"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcs.1854"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12110"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-005-0984-7"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.01038"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering4010005"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.11.021"},{"key":"e_1_2_9_38_2","first-page":"817","article-title":"FEM evaluation of cemented-retained versus screw-retained dental implant single-tooth crown prosthesis","volume":"7","author":"Cicciu M.","year":"2014","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_9_39_2","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1029574","article-title":"FEM and von Mises analysis on prosthetic crowns structural elements: evaluation of different applied materials","volume":"2017","author":"Bramanti E.","year":"2017","journal-title":"The ScientificWorld Journal"},{"key":"e_1_2_9_40_2","article-title":"A patient specific biomechanical analysis of custom root analogue implant designs on alveolar bone stress: a finite element study","volume":"2016","author":"Moin D. A.","year":"2016","journal-title":"International Journal of Dentistry"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.08.024"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.06.018"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.103700"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5611"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2013.09.013"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5254"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820241107"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2006.04.007"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2015.07.012"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2013.12.005"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2012.02.020"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.103823"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.04.004"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2013.05.024"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2006.01.004"},{"key":"e_1_2_9_56_2","first-page":"237","article-title":"Stress tests of reconstruction plates for bridging mandibular angle defects","volume":"8","author":"Knoll W. D.","year":"2004","journal-title":"Mund Kiefer Gesichtschir"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(92)90596-3"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2263-3"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1938.0050"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0096-4174(18)30128-8"},{"key":"e_1_2_9_61_2","first-page":"1","article-title":"Physics-based simulation of biological structures equations for modeling the forces generated by muscles and tendons","author":"Anderson C.","year":"2007","journal-title":"Bioe215"},{"volume-title":"Three Dimensional Computer Modeling of Human Mandibular Biomechanics","year":"1986","author":"Nelson G. J.","key":"e_1_2_9_62_2"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0021-8782.2002.00108.x"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma12071019"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-019-01215-4"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10100844"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-804179-6.00006-X"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.11.006"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/micr.22471"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24480"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2016.03.007"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.10.021"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e318241bac7"},{"key":"e_1_2_9_74_2","doi-asserted-by":"crossref","unstructured":"AmerinatanziA. Shayesteh MoghaddamN. IbrahimH. andElahiniaM. The effect of porosity type on the mechanical performance of porous niti bone implants ASME 2016 Conference on Smart Materials Adaptive Structures and Intelligent Systems 2016 Stowe Vermont USA.","DOI":"10.1115\/SMASIS2016-9293"},{"key":"e_1_2_9_75_2","article-title":"SPIE smart structures and materials+ nondestructive evaluation and health monitoring","author":"Raad B.","year":"2015","journal-title":"International Society for Optics and Photonics"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32500"},{"volume-title":"Toward patient specific long lasting metallic implants for mandibular segmental defects","year":"2015","author":"Shayesteh Moghaddam N.","key":"e_1_2_9_77_2"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmatprotec.2016.06.035"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.84B8.0841093"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1108\/RPJ-11-2017-0231"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1080\/01495739508946316"},{"key":"e_1_2_9_82_2","unstructured":"ZhaoJ.-Z. Saint-Venant\u2019s principle: rationalized and rational."},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2010.03.008"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.05.014"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.2798051"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma7128168"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1258\/la.2012.012062"},{"key":"e_1_2_9_88_2","first-page":"124","article-title":"Clinical chemistry examinations of bone and muscle metabolism under stress in the Gottingen miniature pig--an experimental study","volume":"92","author":"Laiblin C.","year":"1979","journal-title":"Berliner und Munchener tierarztliche Wochenschrift"},{"key":"e_1_2_9_89_2","first-page":"15","article-title":"Growth and skeletal development of the pig","volume":"358","author":"Reiland S.","year":"1978","journal-title":"Acta Radiologica. Supplementum"},{"key":"e_1_2_9_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2014.08.005"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/9880454.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/9880454.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/9880454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T20:40:26Z","timestamp":1735677626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/9880454"}},"subtitle":[],"editor":[{"given":"Konstantinos","family":"Michalakis","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/9880454"],"URL":"https:\/\/doi.org\/10.1155\/2022\/9880454","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9880454"}}