{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:52:18Z","timestamp":1747191138647,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2022,2,27]]},"abstract":"<jats:p>Immunocompromised patients with acquired immunodeficiency syndrome (AIDS) can develop opportunistic esophageal candidial and cytomegaloviral infections. A case is reported which extends the clinico-endoscopic severity of these infections. A 32-year-old bisexual man with AIDS since 1997, and intermittently compliant with antiretroviral therapy, presented (2007) with dysphagia and 32\u2009kg-weight loss. EGD revealed a massive, cheesy, esophageal mucosal exudate from Candida albicans. Cytomegalovirus was isolated by viral culture. The patient improved after fluconazole\/ganciclovir therapy. The patient re-presented (2019) with hematemesis and dysphagia. EGD revealed cheesy esophageal exudate and profound \u201cpunched out\u201d esophageal ulcers mimicking pseudo-diverticula. Histopathology confirmed candidiasis. Viral cultures revealed cytomegalovirus. Barium esophagram revealed deep esophageal ulcers\/pseudo-diverticula. Repeat EGD 8 weeks later after ganciclovir\/micafungin therapy revealed mostly healed lesions. This demonstrates that AIDS patients may have massive mucosal esophageal candidiasis; that both infections can recur years after apparent eradication; and that cytomegaloviral esophageal ulcers may be profound and mimic pseudo-diverticula. A comprehensive literature review revealed only one abstract of esophageal pseudo-diverticula associated with cytomegalovirus. Simultaneous esophageal candidial and CMV infections have also been rarely reported in immunocompromised patients without AIDS.<\/jats:p>","DOI":"10.1155\/2022\/9956650","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T23:05:09Z","timestamp":1646003109000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous Massive Esophageal Mucosal Candidiasis and Profound Cytomegaloviral Esophageal Ulcers with Recurrence of Both Infections 12 Years Later in a Patient with Long-Standing AIDS: Endoscopic, Radiologic, and Pathologic Findings"],"prefix":"10.1155","volume":"2022","author":[{"given":"Inayat","family":"Gill","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, William Beaumont Hospital at Royal Oak, 3535 W. Thirteen Mile Rd, Royal Oak, MI 48073, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Edhi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, William Beaumont Hospital at Royal Oak, 3535 W. Thirteen Mile Rd, Royal Oak, MI 48073, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitual","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pathology, William Beaumont Hospital at Royal Oak, 3600 W. Thirteen Mile Rd, Royal Oak, MI 48073, USA"},{"name":"Department of Pathology, Oakland University William Beaumont School of Medicine, 3600 W. Thirteen Mile Rd, Royal Oak, MI 48073, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-5428","authenticated-orcid":true,"given":"Mitchell S.","family":"Cappell","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Building 1, Room 3210, Aleda E. Lutz VA Medical Center, 1500 Weiss St, Saginaw, MI 48602, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(76)80347-2"},{"volume-title":"Cytomegalovirus Esophagitis","year":"2020","author":"L. 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Li","key":"15"}],"container-title":["Case Reports in Gastrointestinal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crigm\/2022\/9956650.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crigm\/2022\/9956650.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crigm\/2022\/9956650.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T23:05:13Z","timestamp":1646003113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crigm\/2022\/9956650\/"}},"subtitle":[],"editor":[{"given":"Yoshifumi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,27]]},"references-count":15,"alternative-id":["9956650","9956650"],"URL":"https:\/\/doi.org\/10.1155\/2022\/9956650","relation":{},"ISSN":["2090-6536","2090-6528"],"issn-type":[{"type":"electronic","value":"2090-6536"},{"type":"print","value":"2090-6528"}],"subject":[],"published":{"date-parts":[[2022,2,27]]}}}