{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:50:35Z","timestamp":1790139035694,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chongqing Science and Technology Committee","award":["cstc2017shmsA130069"],"award-info":[{"award-number":["cstc2017shmsA130069"]}]},{"name":"Chongqing Science and Technology Committee","award":["2022ZDXM004"],"award-info":[{"award-number":["2022ZDXM004"]}]},{"name":"Joint project of Chongqing Health Commission and Science and Technology Bureau","award":["cstc2017shmsA130069"],"award-info":[{"award-number":["cstc2017shmsA130069"]}]},{"name":"Joint project of Chongqing Health Commission and Science and Technology Bureau","award":["2022ZDXM004"],"award-info":[{"award-number":["2022ZDXM004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2022,3,16]]},"abstract":"<jats:p>Objective. The objective of the study is to investigate the relationships between fetuin-B, thyroid autoimmunity (TAI), and pregnancy outcomes in women undergoing in vitro fertilization and embryo transfer (IVF-ET). Design, Patients, and Measurements. In this prospective study, 180 women who were preparing for pregnancy with IVF-ET were included. There were 120 women with TAI positive and 60 negative controls matched with age and BMI. Results. The 180 women had mean\u2009\u00b1\u2009SD age of 31.4\u2009\u00b1\u20094.0\u2009years, with a mean\u2009\u00b1\u2009SD BMI of 21.0\u2009\u00b1\u20091.6\u2009kg\/m2. There was a significant difference in the level of fetuin-B in women with TAI positive compared with TAI negative group (65.2\u2009\u00b1\u200918.5 vs. 76.4\u2009\u00b1\u200925.1, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Fetuin-B had a negative relationship with thyroid antibodies even after adjusting for other variables (OR (95%CI)\u2009=\u20090.98 (0.96\u20130.99), <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.002<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Compared with women with TAI negative, those with TAI positive had a significantly higher risk of low fertilization (20.0% vs. 6.7%; <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.035<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). And we found no difference in terms of pregnancy, abortion, implantation, and live birth rate between the two groups. Logistic regression analysis showed that both fetuin-B and TAI were the independent factors to lead the low fertilization of IVF-ET (OR (95%CI)\u2009=\u20090.96 (0.94\u20130.99) and 4.084 (1.39\u201315.30), <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.004<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula> and 0.019, respectively). Conclusion. Fetuin-B was significantly associated with TAI and low fertilization rate in women undergoing IVF-ET. Decreased fetuin-B in women with TAI may be the underlying reason for the lower IVF-ET success rate.<\/jats:p>","DOI":"10.1155\/2022\/9961253","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T23:20:45Z","timestamp":1647472845000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["The Relationships among Plasma Fetuin-B, Thyroid Autoimmunity, and Fertilization Rate In Vitro Fertilization and Embryo Transfer"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3607-5138","authenticated-orcid":true,"given":"Rui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8541-8734","authenticated-orcid":true,"given":"Feifei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-8759","authenticated-orcid":true,"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4729-9209","authenticated-orcid":true,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7562-6417","authenticated-orcid":true,"given":"Binghan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Chongqing People\u2019s Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-3625","authenticated-orcid":true,"given":"Mingyuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5673-0622","authenticated-orcid":true,"given":"Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8801-2190","authenticated-orcid":true,"given":"Dongfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"2911","article-title":"Type 3 cystatins; fetuins, kininogen and histidine-rich glycoprotein","volume":"14","author":"W. 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