{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:47:12Z","timestamp":1778701632209,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anemia"],"published-print":{"date-parts":[[2022,2,3]]},"abstract":"<jats:p>Introduction. Sickle cell disease is an autosomal recessive inherited disorder due to the mutation of a gene coding for the globin beta chain. The aim of this study is to update the epidemiological data on hemoglobinoses, in particular sickle cell disease in newborns in Congo. Materials and Methods. This was a descriptive cross-sectional study, conducted from October 1, 2019, to March 31, 2020, throughout the Congolese national territory. It involved all full-term newborns, without distinction of nationality, aged 5 days or less, and whose parents consented to participate in the study. The blood samples, taken at the heel and collected on Whatman blotting paper, were analyzed using the HPLC Variant NBS machine. Results. In 2897 newborns (NN) screened, hemoglobin abnormalities were found in 603 NN (20.81%). The mean age of these newborns was 1 day (extremes 0 and 5 days). The male-to-female ratio was 1.03. Abnormal hemoglobins were mainly Hb S (n\u2009=\u2009597 (97.71%)); Hb C (n\u2009=\u20095 (0.82%)); and variants (n\u2009=\u20097 (1.15%)). The national prevalence of major sickle cell (MSC) syndromes and sickle cell trait was 1.35% and 19.43%, respectively. The prevalence ranged from 1.77% to 2.56% for MSS in four departments and from 20.5% to 25.8% for the sickle cell trait in six other departments. Conclusion. Data on homozygous sickle cell disease remain consistent with previous studies. However, further studies should clarify the molecular anomalies of the variants observed in our samples.<\/jats:p>","DOI":"10.1155\/2022\/9970315","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:08:30Z","timestamp":1643933310000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Neonatal Screening for Sickle Cell Disease in Congo"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2819-6872","authenticated-orcid":true,"given":"Alexis Elira","family":"Dokekias","sequence":"first","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la Dr\u00e9panocytose \u2018\u2019 Antoinette SASSOU N\u2019GUESSO, Brazzaville, Congo"},{"name":"Universit\u00e9 Marien Ngouabi, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9006-5980","authenticated-orcid":true,"given":"Lethso Thibaut","family":"Ocko Gokaba","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la Dr\u00e9panocytose \u2018\u2019 Antoinette SASSOU N\u2019GUESSO, Brazzaville, Congo"},{"name":"Universit\u00e9 Marien Ngouabi, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0833-8167","authenticated-orcid":true,"given":"Josu\u00e9 Simo","family":"Louokdom","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la Dr\u00e9panocytose \u2018\u2019 Antoinette SASSOU N\u2019GUESSO, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8757-8136","authenticated-orcid":true,"given":"Lydie Ngolet","family":"Ocini","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la Dr\u00e9panocytose \u2018\u2019 Antoinette SASSOU N\u2019GUESSO, Brazzaville, Congo"},{"name":"Universit\u00e9 Marien Ngouabi, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4444-7547","authenticated-orcid":true,"given":"Firmine Olivia","family":"Galiba Atipo Tsiba","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la Dr\u00e9panocytose \u2018\u2019 Antoinette SASSOU N\u2019GUESSO, Brazzaville, Congo"},{"name":"Universit\u00e9 Marien Ngouabi, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coreillia Ir\u00e8ne","family":"Ondzotto Ibatta","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la Dr\u00e9panocytose \u2018\u2019 Antoinette SASSOU N\u2019GUESSO, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin Ngoma","family":"Kouandzi","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la Dr\u00e9panocytose \u2018\u2019 Antoinette SASSOU N\u2019GUESSO, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge Talomg","family":"Tamekue","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la Dr\u00e9panocytose \u2018\u2019 Antoinette SASSOU N\u2019GUESSO, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1543-101X","authenticated-orcid":true,"given":"Jayne Chelsea","family":"Bango","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la Dr\u00e9panocytose \u2018\u2019 Antoinette SASSOU N\u2019GUESSO, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade Vanessa","family":"Nziengui Mboumba","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la Dr\u00e9panocytose \u2018\u2019 Antoinette SASSOU N\u2019GUESSO, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon Charles","family":"Kobawila","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Marien Ngouabi, Brazzaville, Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.10"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36077-w"},{"key":"3","article-title":"Sickle cell disease","volume":"2016","author":"M. 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