{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:19:15Z","timestamp":1740140355980,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["2021A185","202120073"],"award-info":[{"award-number":["2021A185","202120073"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,10,17]]},"abstract":"Objective. This study aimed to observe the clinical efficacy of low-frequency electrical stimulation therapy combined with tonifying the kidney and activating blood pills to promote uterine recovery after abortion and its effect on heat-shock protein (HSP)70 and HSP90. Methods. All cases were women with early pregnancy who underwent an abortion at the Third Affiliated Hospital of Nanchang University from September 2019 to September 2020. They were divided into two groups in accordance with the principle of patient voluntariness: 237 cases in the experimental group and 143 cases in the control group. Patients in both groups were given low-frequency electrical stimulation after surgery. In addition, patients in the experimental group began to take the Dingkun pill orally (one pill per time, two times per day) from the first day of surgery and continued to take it until their menstruation returned to normal. Abdominal pain, the duration of vaginal bleeding, and the amount of bleeding were observed in both groups. Uterine size, endometrial thickness, and urinary human chorionic gonadotropin (HCG) status were also observed at 2 weeks postoperatively to determine preoperative and postoperative HSP70 and HSP90 serum levels. The time of menstrual resumption, menstrual period, and menstrual volume were observed and compared with preoperative menstruation. The occurrence of complications, such as a residual uterine cavity, uterine effusion, menstrual irregularities, and reproductive tract infections, during the follow-up period was also recorded in both groups. Results. Comparison of the endometrial thickness (mm) and uterine size (sum of the three diameters) on uterine adnexal ultrasound at 2-week postoperative review was better in the experimental group than in the control group (\n \n p<\/a:mi>\n <<\/a:mo>\n 0.05<\/a:mn>\n <\/a:math>\n <\/jats:inline-formula>). No statistically significant difference was found between the two groups in terms of residual uterine cavity and blood accumulation in the uterine cavity and the results of the urine pregnancy test (\n \n p<\/c:mi>\n ><\/c:mo>\n 0.05<\/c:mn>\n <\/c:math>\n <\/jats:inline-formula>). Serum HSP70 and HSP90 levels were significantly higher in the control group than in the experimental group 2 weeks after surgery (\n \n p<\/e:mi>\n <<\/e:mo>\n 0.05<\/e:mn>\n <\/e:math>\n <\/jats:inline-formula>). Postoperative HSP70 and HSP90 levels were significantly higher than preoperative levels in both groups (\n \n p<\/g:mi>\n <<\/g:mo>\n 0.05<\/g:mn>\n <\/g:math>\n <\/jats:inline-formula>). The degree of postoperative abdominal pain in the experimental group was less severe than that in the control group, and the duration was shorter (\n \n p<\/i:mi>\n <<\/i:mo>\n 0.05<\/i:mn>\n <\/i:math>\n <\/jats:inline-formula>). No statistically significant differences were observed when comparing the duration of postoperative vaginal bleeding and the amount of bleeding (\n \n p<\/k:mi>\n ><\/k:mo>\n 0.05<\/k:mn>\n <\/k:math>\n <\/jats:inline-formula>). The time of the first menstrual resumption and menstrual volume were more satisfactory in the experimental group than in the control group (\n \n p<\/m:mi>\n <<\/m:mo>\n 0.05<\/m:mn>\n <\/m:math>\n <\/jats:inline-formula>). No adverse reactions occurred in either group of patients receiving treatment. Conclusion.Low-frequency electrical stimulation combined with tonifying the kidney and invigorating blood pills could effectively promote uterine rejuvenation after abortion, conducive to improving patients\u2019 postoperative abdominal pain, promoting menstrual recovery and maintaining menstrual flow.<\/jats:p>","DOI":"10.1155\/2022\/9976063","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T20:35:08Z","timestamp":1666038908000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Low-Frequency Electrical Stimulation Combined with Tonifying Kidney and Blood Pills on Uterine Rejuvenation after Abortion"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8269-4813","authenticated-orcid":true,"given":"Man","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Nanchang University, Nanchang First Hospital, Nanchang University, Nanchang, Jiangxi 330006, China"},{"name":"Department of Obstetrics and Gynecology, Huanggang Traditional Chinese Medicine Hospital, Huanggang, Hubei 438000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-0332","authenticated-orcid":true,"given":"Shi-Xin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Nanchang University, Nanchang First Hospital, Nanchang University, Nanchang, Jiangxi 330006, China"},{"name":"School of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4489-7510","authenticated-orcid":true,"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Nanchang University, Nanchang First Hospital, Nanchang University, Nanchang, Jiangxi 330006, China"},{"name":"School of Clinical Medicine, Nanchang University, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1960-7817","authenticated-orcid":true,"given":"Xin-Tong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Nanchang University, Nanchang First Hospital, Nanchang University, Nanchang, Jiangxi 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5099-3720","authenticated-orcid":true,"given":"Ai-Hua","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Huanggang Traditional Chinese Medicine Hospital, Huanggang, Hubei 438000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4086-1086","authenticated-orcid":true,"given":"Jun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7289-083X","authenticated-orcid":true,"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"14","key":"1","first-page":"2209","article-title":"The effect of biomimetic technology on the recovery of gastrointestinal function and relief of abdominal distension in the rehabilitation of postoperative gynecological patients","volume":"38","author":"L. 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Zheng","year":"2019","journal-title":"Modern Chinese and Western Medicine Journal"},{"issue":"7","key":"10","first-page":"691","article-title":"[Anesthetic effect of preemptive analgesia of frequency acupoint electrical stimulation on painless-induced abortion]","volume":"34","author":"Li-H. Wang","year":"2014","journal-title":"Zhongguo Zhen Jiu"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.13703\/j.0255-2930.20190824-0001"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1016\/j.ijsu.2016.04.042"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.13703\/j.0255-2930.2017.02.018"},{"key":"14","first-page":"20","article-title":"Effect of lower abdominal transcutaneous electrical stimulation on postoperative endometrial thickness and hemodynamics in women with indolent and incomplete abortions","volume":"27","author":"Mi-R. 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