{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:22:54Z","timestamp":1790875374201,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yunnan Provincial Health and Family Planning Commission Medical Reserve Talent Training Program","award":["H-201604"],"award-info":[{"award-number":["H-201604"]}]},{"name":"Yunnan Provincial Health and Family Planning Commission Medical Reserve Talent Training Program","award":["2018FE001(-232)"],"award-info":[{"award-number":["2018FE001(-232)"]}]},{"name":"Yunnan Basic Research Project","award":["H-201604"],"award-info":[{"award-number":["H-201604"]}]},{"name":"Yunnan Basic Research Project","award":["2018FE001(-232)"],"award-info":[{"award-number":["2018FE001(-232)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2022,1,24]]},"abstract":"<jats:p>Tumor-associated macrophage (TAM) is a major component of tumor microenvironment (TME) and plays critical role in the progression of cancer metastasis. However, TAM-mediated regulation in gallbladder cancer (GBC) has not been fully characterized. Here, we found that exosomes derived from GBC cell polarized macrophage to M2 phenotype, which then facilitated the invasion and migration of GBC cells. We discovered that leptin was enriched in GBC cell-derived exosomes. Exosomal leptin levels promoted invasion and migration of GBC-SD cells. The inhibition of leptin not only attenuated M2 macrophage of polarization but also inhibited the invasive and migratory ability of GBC cell. In addition, GBC-SD cell-derived exosomal leptin induced M2 polarization of macrophage via activation of STAT3 signal pathway. Taken together, our results suggested that GBC cells secrete exosome-enclosed leptin facilitated cell invasion and migration via polarizing TAM.<\/jats:p>","DOI":"10.1155\/2022\/9994906","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T04:05:14Z","timestamp":1643083514000},"page":"1-11","source":"Crossref","is-referenced-by-count":22,"title":["Gallbladder Cancer Cell-Derived Exosome-Mediated Transfer of Leptin Promotes Cell Invasion and Migration by Modulating STAT3-Mediated M2 Macrophage Polarization"],"prefix":"10.1155","volume":"2022","author":[{"given":"Songling","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Basic Medical College, Kunming Medical University, Kunming City, Yunnan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhai","family":"He","sequence":"additional","affiliation":[{"name":"Department of General Surgery, People\u2019s Hospital of Xishuangbanna Dai Autonomous Prefecture, Xishuangbanna Dai Autonomous Prefecture, Yunnan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Lin","sequence":"additional","affiliation":[{"name":"Central Operating Room, The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-418X","authenticated-orcid":true,"given":"Hao","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0878-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0579-8"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.05.002"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614035114"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0312-y"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1159\/000479269"},{"key":"7","first-page":"13","article-title":"Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells, cell communication and signaling","volume":"17","author":"B. 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