{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:52:58Z","timestamp":1747191178753,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2023,5,23]]},"abstract":"<jats:p>Mammary Paget\u2019s disease (MPD) is a rare histological condition, accounting for 1-4% of female breast cancers, which may appear either independently (1.4-13% of the cases), or in association with an in situ or invasive ductal carcinoma (approximately 90% of the cases). The purpose of this article is to highlight the histopathological challenges related to the microscopical polymorphism of this disease and the utmost importance of immunohistochemistry in the thorough process of Paget\u2019s disease differential diagnosis. Moreover, the primary objective of this review of literature was to corroborate the existing data concerning the potential peculiar immunohistochemical profile that mammary Paget\u2019s disease might express. We report the case of a 44-year-old female patient, histopathologically diagnosed with HER2-negative MPD accompanying an invasive mammary carcinoma. The histopathological and immunohistochemical approach is derived from the exigency of excluding the possibility of synchronous tumors\u2014a mammary invasive carcinoma, accompanied by another component with MPD phenotypic mimicry. The unexpected negative HER2 reaction is conducted to a primary focus on excluding a malignant melanoma in situ. The absence of MelanA and S100 immunoexpression and lack of pigmentation and clinical aspects infirmed it. Bowen\u2019s disease was invalidated by its rare presentation in the breast cutaneous tissue and the absence of individual risk factors suggestive of an existing immunosuppressive status. In the case of similar morphoimmunohistochemical aspects, significant expression of Ki-67 signals MPD, an immunoreactivity that helped distinguish the cellular population from Toker cells. The great similarity of MPD with other benign and malignant cutaneous tumors might determine delay or misdiagnosis. Thus, the utmost importance of immunohistochemistry is reflected in its prognostic significance and geared towards extending the therapeutic arsenal.<\/jats:p>","DOI":"10.1155\/2023\/1101130","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T16:20:44Z","timestamp":1684858844000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["HER2 Negative Mammary Paget\u2019s Disease or In Situ Melanoma? A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-4900","authenticated-orcid":true,"given":"Luana-Andreea","family":"Bo\u0219oteanu","sequence":"first","affiliation":[{"name":"Department of Dermatology, \u201cElias\u201d Emergency University Hospital, Bucharest, Romania"},{"name":"Institute of Doctoral Studies, Doctoral School of Medicine, \u201cOvidius\u201d University of Constanta, Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4255-586X","authenticated-orcid":true,"given":"Mariana","family":"A\u0219chie","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSaint Andrew\u201d Emergency County Hospital, Constanta, Romania"},{"name":"Department of Pathology, Faculty of Medicine, \u201cOvidius\u201d University of Constanta, Romania"},{"name":"Department VIII-Medical Sciences, Academy of Romanian Scientists, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8039-3200","authenticated-orcid":true,"given":"Cristian Ionu\u0163","family":"Or\u01ce\u0219anu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSaint Andrew\u201d Emergency County Hospital, Constanta, Romania"},{"name":"Department of Pathology, Faculty of Medicine, \u201cOvidius\u201d University of Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-1128","authenticated-orcid":true,"given":"M\u0103d\u0103lina","family":"Bo\u0219oteanu","sequence":"additional","affiliation":[{"name":"Clinical Service of Pathology, \u201cSaint Andrew\u201d Emergency County Hospital, Constanta, Romania"},{"name":"Department of Pathology, Faculty of Medicine, \u201cOvidius\u201d University of Constanta, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.21.5.303"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2017.00051"},{"key":"3","volume-title":"Dermatology","author":"J. 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Kanitakis","year":"2007","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800437"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10638"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.1024"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2242"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.21037\/abs.2019.05.01"}],"container-title":["Case Reports in Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2023\/1101130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2023\/1101130.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2023\/1101130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T20:36:16Z","timestamp":1702499776000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cripa\/2023\/1101130\/"}},"subtitle":[],"editor":[{"given":"Samir Sami","family":"Amr","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":33,"alternative-id":["1101130","1101130"],"URL":"https:\/\/doi.org\/10.1155\/2023\/1101130","relation":{},"ISSN":["2090-679X","2090-6781"],"issn-type":[{"type":"electronic","value":"2090-679X"},{"type":"print","value":"2090-6781"}],"subject":[],"published":{"date-parts":[[2023,5,23]]}}}