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This study aimed to analyze the antihyperglycemic and antioxidant roles of the 1,3,4\u2010oxadiazole derivative with its toxicity. Diabetes was induced through intraperitoneal administration of alloxan monohydrate at 150\u2009mg\/kg in rats. Glimepiride and acarbose were used as standards. Rats were divided into groups of normal control, disease control, standard, and diabetic rats (treated with 5, 10, and 15\u2009mg\/kg of 1,3,4\u2010oxadiazole derivative). After 14\u2009days of oral administration of 1,3,4\u2010oxadiazole derivatives (5, 10, and 15\u2009mg\/kg) to the diabetic group, the blood glucose level, body weight, glycated hemoglobin (HbA1c), insulin level, antioxidant effect, and histopathology of the pancreas were performed. The toxicity was measured by estimating liver enzyme, renal function, lipid profile, antioxidative effect, and liver and kidney histopathological study. The blood glucose and body weight were measured before and after treatment. Alloxan significantly increased blood glucose levels, HbA1c, alanine transaminase, aspartate aminotransferase, urea, cholesterol, triglycerides, and creatinine. In contrast, body weight, insulin level, and antioxidant factors were reduced compared to the normal control group. Treatment with oxadiazole derivatives showed a significant reduction in blood glucose levels, HbA1c, alanine transaminase, aspartate aminotransferase, urea, cholesterol, triglycerides, and creatinine as compared to the disease control group. The 1,3,4\u2010oxadiazole derivative significantly improved body weight, insulin level, and antioxidant factors compared to the disease control group. In conclusion, the oxadiazole derivative showed potential antidiabetic activity and indicated its potential as a therapeutic.<\/jats:p>","DOI":"10.1155\/2023\/1141554","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T22:05:09Z","timestamp":1682460309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of Antidiabetic Activity of Oxadiazole Derivative in Rats"],"prefix":"10.1155","volume":"2023","author":[{"given":"Adil Iqbal","family":"Qazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashir","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9768-4255","authenticated-orcid":false,"given":"Muhammad Umar Khayam","family":"Sahibzada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fareeha","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer","family":"Khusro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-8309","authenticated-orcid":false,"given":"Fahad A.","family":"Alhumaydhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-2675","authenticated-orcid":false,"given":"Amany Abdel-Rahman","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4947-0495","authenticated-orcid":false,"given":"Gomaa","family":"Mostafa-Hedeab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-2272","authenticated-orcid":false,"given":"Talha Bin","family":"Emran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.12.032"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.15419\/bmrat.v8i3.663"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-00443-4"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.109945"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)30058-2"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01786"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/414821a"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.07.069"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-020-10125-y"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2115036"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods10081939"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph15081035"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.7555\/jbr.31.20160164"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/572013"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph13060111"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm2013248"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2007.06.026"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-008096519-2.00091-6"},{"key":"e_1_2_9_19_2","first-page":"21","article-title":"Antidiabetic activity of ethanolic leaf extract of Croton zambesicus Muell. 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