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The treatment options for patients with skin cutaneous melanoma (SKCM) vary based on BRAF V600E statuses. However, all standard treatments include immunotherapy. Therefore, it is critical to identify ICD\u2010associated signatures that can help classify patients according to benefits from ICD immunotherapy. In this study, data on melanoma samples with BRAF V600E mutation (BRAF V600E\u2010mutant melanoma) and melanoma samples with wild\u2010type BRAF V600E alleles (BRAF V600E WT melanoma) were collected from The Cancer Genome Atlas (TCGA) database. The ICD\u2010related (ICD\u2010high and ICD\u2010low) subgroups of patients with BRAF V600E WT melanoma were established via consensus clustering. The analyses of survival, differentially expressed genes (DEGs), functional annotation, and immune landscape were performed in these two subgroups. Results showed that ICD\u2010high subgroup was correlated with a positive overall survival (OS) and active tumor immune landscape. A model comprising seven prognosis ICD\u2010related gene biomarkers was developed. Survival analysis and receiver operating characteristic (ROC) curve evaluation in both cohorts with BRAF V600E WT and BRAF V600E\u2010mutant melanoma showed an accurate prognostic estimation of ICD\u2010related risk signature. There was a correlation between immune cell infiltration and immunotherapy response and risk score. Thus, the ICD risk signature was closely associated with the tumor\u2019s immune microenvironment. Our results may provide insights to further individualize and improve precision therapeutic decision\u2010making in BRAF V600E\u2010mutant and WT melanoma.<\/jats:p>","DOI":"10.1155\/2023\/1189022","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T14:35:07Z","timestamp":1673879707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An Immunogenic Cell Death\u2010Related Gene Signature Reflects Immune Landscape and Predicts Prognosis in Melanoma Independently of BRAF V600E 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