{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:51:06Z","timestamp":1781304666993,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":100,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Resistance to common antimalarial drugs and persistence of the endemicity of malaria constitute a major public health problem in Cameroon. The aim of this study was to evaluate the <jats:italic>in vitro<\/jats:italic> antiplasmodial, antioxidant, and cytotoxic activities of aqueous and ethanol extracts of <jats:italic>Bridelia micrantha<\/jats:italic> used by Cameroonian traditional healers for the treatment of malaria. <jats:italic>Methods<\/jats:italic>. Aqueous and ethanolic stem bark extracts were prepared according to standard procedures. The SYBR Green method was used for antiplasmodial activity on strains of <jats:italic>Plasmodium falciparum<\/jats:italic> sensitive to chloroquine (3D7) and resistant (Dd2). <jats:italic>In vitro<\/jats:italic> antioxidant activities of <jats:italic>B. micrantha<\/jats:italic> were determined using the scavenging activity of 2,2\u2032\u2010diphenyl\u20101\u2010picrylhydrazyl, nitric oxide, ferric reducing power, and hydrogen peroxide as well as their cytotoxicity on RAW 264.7 macrophage cells and red blood cells (RBC). <jats:italic>Results<\/jats:italic>. The aqueous and ethanol extracts of <jats:italic>Bridelia micrantha<\/jats:italic> showed antiplasmodial activity on the 3D7 strain with IC<jats:sub>50<\/jats:sub> of 31.65 \u00b1 0.79\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml and 19.41 \u00b1 2.93\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, respectively, as well as 37.64 \u00b1 0.77\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml and 36.22 \u00b1 1.04\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml for the Dd2 strain, respectively. The aqueous and ethanol extracts showed free radical scavenging properties. The IC<jats:sub>50<\/jats:sub> aqueous and ethanol extract was approximately 0.0001737\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, 42.92\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, 1197\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, 63.78\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml and 4.617\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, 429.9\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, 511\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, and 69.32\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml for DPPH, NO, H2O2, and FRAP, respectively, which were compared to ascorbic acid (8.610<jats:italic>e<\/jats:italic> \u2212 005\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, 2901\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, 3237\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, and 18.57\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml). The aqueous and ethanol extracts of <jats:italic>B. micrantha<\/jats:italic> were found to be nontoxic with CC<jats:sub>50<\/jats:sub> values of 950 \u00b1 6.6\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml and 308.3 \u00b1 45.4\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, respectively. Haemolysis test showed that the two extracts were not toxic. <jats:italic>Conclusion<\/jats:italic>. These results suggest that <jats:italic>B. micrantha<\/jats:italic> can serve as an antimalarial agent. However, further studies are needed to validate the use of <jats:italic>B. micrantha<\/jats:italic> as an antimalarial.<\/jats:p>","DOI":"10.1155\/2023\/1219432","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T20:20:09Z","timestamp":1681244409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antiplasmodial, Antioxidant, and Cytotoxic Activity of <i>Bridelia micrantha<\/i> a Cameroonian Medicinal Plant Used for the Treatment of Malaria"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4042-6327","authenticated-orcid":false,"given":"Tako Djimefo Alex","family":"Kevin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-4296","authenticated-orcid":false,"given":"Yamssi","family":"Cedric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2393-9841","authenticated-orcid":false,"given":"Noumedem Anangmo Christelle","family":"Nadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2599-6310","authenticated-orcid":false,"given":"Ngouyamsa Nsapkain Aboubakar","family":"Sidiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounvera Abdel","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3134-4549","authenticated-orcid":false,"given":"Gamago Nkadeu","family":"Guy-Armand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3045-9886","authenticated-orcid":false,"given":"Tientcheu Noutong Jemimah","family":"Sandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8063-7815","authenticated-orcid":false,"given":"Mbohou Nchetnkou","family":"Christian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2599-2506","authenticated-orcid":false,"given":"Essangui Same Estelle","family":"G\u00e9raldine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1013-7357","authenticated-orcid":false,"given":"Tankoua-Tchounda","family":"Rom\u00e9o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2941-988X","authenticated-orcid":false,"given":"Vincent Khan","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0182-3212","authenticated-orcid":false,"given":"Lehmann L\u00e9opold","family":"Gustave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2011.12.007"},{"key":"e_1_2_10_2_2","unstructured":"ChoutoS.andWakponouA. 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