{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:49:42Z","timestamp":1773456582808,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tai\u2019an Science and Technology Development Fund","award":["2021NS201"],"award-info":[{"award-number":["2021NS201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2023,2,21]]},"abstract":"<jats:p>Objective. To investigate the relationship between angiotensin II (Ang II), vascular endothelial growth factor (VEGF), and arteriosclerosis obliterans (ASO). Methods. 60 ASO patients diagnosed and treated from October 2019 to December 2021 were selected for the observation group while 30 healthy physical examiners were for the control group. The general information (gender, age, history of smoking, diabetes, and hypertension) and arterial blood pressure (systolic and diastolic blood pressure) of the two groups were collected, and parameters like disease site and duration, Fontaine stage, and ankle-brachial index (ABI) of ASO patients have been evaluated. Ang II, VEGF, uric acid (UA), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), and total cholesterol (TC) were also detected for the two groups. The variations in UA, LDL, HDL, TG, and TC among two groups along with levels of Ang II and VEGF in ASO patients in accordance to conditions like the general situation, disease duration, disease site, Fontaine stage, and ABI risk level have been studied to establish a correlation between Ang II and VEGF and ASO. Results. (1) The proportion of males with a history of smoking, diabetes, and hypertension was higher (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) among ASO patients in comparison to the control group. The diastolic blood pressure, LDL, TC, Ang II, and VEGF levels were found to be higher (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) whereas HDL was low (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.01<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). (2) The level of Ang II in male patients with ASO was significantly higher than that in female ASO patients (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). In ASO patients, the levels of Ang II and VEGF increased not only with age (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.01<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>) but also with progression in Fontaine stages II, III, and IV (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.01<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). (3) Logistic regression analysis revealed Ang II and VEGF as risk factors for ASO. (4) An AUC (area under the ROC (receiver operator characteristic) curve) for Ang II and VEGF for the diagnosis of ASO was 0.764 (good) and 0.854 (very good), respectively, while their combined AUC in diagnosing ASO was 0.901 (excellent). The AUC of Ang II and VEGF together in diagnosing ASO was greater than that of Ang II and VEGF alone along with higher specificity as well (all <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.05<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>). Conclusion. Ang II and VEGF were correlated with the occurrence and development of ASO. The AUC analysis demonstrates that Ang II and VEGF were highly discriminative of ASO.<\/jats:p>","DOI":"10.1155\/2023\/1316821","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T21:54:40Z","timestamp":1677016480000},"page":"1-13","source":"Crossref","is-referenced-by-count":6,"title":["Relationship between Angiotensin II, Vascular Endothelial Growth Factor, and Arteriosclerosis Obliterans"],"prefix":"10.1155","volume":"2023","author":[{"given":"Yulian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Interventional Diagnosis and Treatment, Tai\u2019an Traditional Chinese Medicine Hospital, Tai\u2019an 271000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhi","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Interventional Diagnosis and Treatment, Tai\u2019an Traditional Chinese Medicine Hospital, Tai\u2019an 271000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongqi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Interventional Diagnosis and Treatment, Tai\u2019an Traditional Chinese Medicine Hospital, Tai\u2019an 271000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Second Affiliated Hospital of Shandong First Medical University, Tai\u2019an 271000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4846-3074","authenticated-orcid":true,"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Peripheral Vascular Diseases, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-2785","authenticated-orcid":true,"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Second Affiliated Hospital of Shandong First Medical University, Tai\u2019an 271000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000455986"},{"key":"2","volume-title":"Practical Peripheral Vascular Diseases","author":"H. Yufen","year":"2005","edition":"1st"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnc.2018.11.003"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02084-w"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0169-2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.27238"},{"issue":"6","key":"8","first-page":"141","article-title":"Relationship between angiotensin II and coronary heart disease","volume":"34","author":"L. Qingquan","year":"2012","journal-title":"Fujian Journal of Medicine"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136702"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2015.06.010"},{"issue":"8A","key":"11","doi-asserted-by":"crossref","first-page":"25C","DOI":"10.1016\/S0002-9149(01)01539-9","article-title":"Angiotensin II and atherosclerosis","volume":"87","author":"D. Weiss","year":"2001","journal-title":"The American Journal of Cardiology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115881"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5355"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01534-0"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.08.021"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.4.3"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.4017"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09486-1"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.arteri.2018.04.003"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0768"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.1.131"},{"issue":"2","key":"22","first-page":"309","article-title":"Expression and clinical significance of vascular endothelial cell growth factor and homocysteine in patients with lower extremity arteriosclerosis obliterans","volume":"35","author":"S. Chao","year":"2022","journal-title":"Medical Theory and Practice"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4804(03)00254-3"},{"issue":"3","key":"24","first-page":"145","article-title":"Guidelines for diagnosis and treatment of arteriosclerosis obliterans of lower extremity","volume":"7","author":"Vascular Surgery Group, Surgery Society of Chinese Medical Association","year":"2015","journal-title":"Chinese Journal of Vascular Surgery (Electronic Edition)"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"26","volume-title":"Correlation between lipoprotein phospholipase A2, common femoral artery intima-media thickness and traditional Chinese medicine syndrome type of occlusive arteriosclerosis obliterans","author":"W. Zhankun","year":"2020"},{"issue":"6","key":"27","first-page":"675","article-title":"The value of plasma \u03b22-mg and HCY in the risk classification and prognosis assessment of lower extremity atherosclerosis","volume":"21","author":"X. Shuai","year":"2012","journal-title":"Chinese Journal of General Surgery"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3390\/biom8030080"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04544-8"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-021-2877-9"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-314230"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0464-6"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.16430"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.135053"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9805"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.08.072"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2018.08.019"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2022.0278"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.28.20130130"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24247"},{"key":"41","first-page":"217","article-title":"Effect of Captopril on endothelin and angiotensin ? in rabbits with atherosclerosis and its correlation with proto-oncogenes c-myc and c-fos","volume":"3","author":"D. Xiaoyan","year":"2002","journal-title":"Chinese Journal of Arteriosclerosis"},{"key":"42","first-page":"212","article-title":"Relationship between abnormal proliferation of aortic smooth muscle cells and endogenous renin-angiotensin system in spontaneously hypertensive rats","volume":"3","author":"W. Xiangyu","year":"1997","journal-title":"Chinese Journal of Arteriosclerosis"},{"issue":"24","key":"43","first-page":"6905","article-title":"Association between angiotensin ? and atherosclerosis in type 2 diabetes mellitus","volume":"34","author":"Z. Jingxiong","year":"2014","journal-title":"Chinese Journal of Gerontology"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.09.007"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1159\/000325206"},{"issue":"12","key":"46","first-page":"1461","article-title":"Resveratrol inhibits angiotensin ?\/TLR4\/NF-KB in regulating inflammation and oxidative stress injury of rat vascular smooth muscle cells","volume":"11","author":"L. Dongdong","year":"2019","journal-title":"Chinese Journal of Evidence-based Cardiovascular Medicine"},{"key":"47","volume-title":"Study on the pathology, morphology and related cellular mechanism of carotid atherosclerotic plaque","author":"C. Yiyao","year":"2019"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2023\/1316821.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2023\/1316821.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2023\/1316821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T21:54:54Z","timestamp":1677016494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2023\/1316821\/"}},"subtitle":[],"editor":[{"given":"Yi","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,21]]},"references-count":47,"alternative-id":["1316821","1316821"],"URL":"https:\/\/doi.org\/10.1155\/2023\/1316821","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2,21]]}}}