{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:32:45Z","timestamp":1792481565741,"version":"4.5.0"},"reference-count":120,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. MetS are common throughout the world, including Ethiopia. These have traditionally been treated using medicinal plants, particularly in rural areas where they are freely accessible. This systematic review tried to investigate the treatment of MetS with Ethiopian medicinal herbs and made recommendations for more validation research. A careful analysis of the literature was also conducted on the therapeutic effects of these and other Ethiopian medicinal plants with hepatoprotective and antihypertensive activities. <jats:italic>Methods<\/jats:italic>. The relevant keywords \u201cEthnomedicinal\u2009+\u2009hypertension,\u201d \u201cEthnopharmacological\u2009+\u2009hypertension,\u201d \u201cEthnomedicinal\u2009+\u2009hepatitis, jaundices, and liver disease,\u201d \u201cEthnopharmacological\u2009+\u2009hepatic disorder,\u201d and \u201cEthnomedicinal\u2009+\u2009weight loss\u201d were used to search for relevant articles in the major electronic scientific databases, including PubMed, Science Direct, Web of Science, and Google Scholar. The search strategy included all articles with descriptions that were accessible until April 30, 2022. The study\u2019s subjects, methods, or year of publication were no restrictions in the search. The outcomes were compiled using descriptive statistics. <jats:italic>Results<\/jats:italic>. Fifty\u2010four (54) studies were examined in the review that satisfied the inclusion and exclusion criteria for the treatment of MetS in Ethiopia. The most often used ethnobotanical plant species for the treatment of hypertension and hepatic disorders were <jats:italic>Moringa stenopetala<\/jats:italic> and <jats:italic>Croton macrostachyus<\/jats:italic>. Both hepatic and hypertensive disorders were treated more frequently with leaves (52% and 39%, respectively) than with roots (20% and 13%, respectively). Some intriguing studies came from an ethnobotanical investigation into medicinal herbs\u2019 hepatoprotective and antihypertensive properties. The most often investigated medicinal plant for its antihypertensive effects is <jats:italic>Moringa stenopetala<\/jats:italic>. <jats:italic>Conclusion<\/jats:italic>. The study revealed that Ethiopians often use anti\u2010MetS herbal remedies. We advocate the experimental validation of the commonly used medicinal plants with the identification of active compounds and the development of effective alternative drugs for the treatment of MetS.<\/jats:p>","DOI":"10.1155\/2023\/1413038","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T19:50:10Z","timestamp":1673553010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Traditional Herbal Remedies in the Management of Metabolic Disorders in Ethiopia: A Systematic Review of Ethnobotanical Studies and Pharmacological Activities"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5860-7070","authenticated-orcid":false,"given":"Mekdes Alemu","family":"Tola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fozia","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haregua","family":"Melak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temesgen","family":"Tafesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekdelawit","family":"Alemayehu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7758-6367","authenticated-orcid":false,"given":"Gashaw","family":"Nigussie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12229"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2017.07.004"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2008.0070"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.102"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2006.03.001"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/414821a"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-020-00453-7"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13002-021-00498-1"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.25026\/jtpc.v5i1.241"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0010(20000915)80:12<1744::aid-jsfa725>3.0.co;2-w"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/plants6040042"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2021.11.022"},{"key":"e_1_2_8_13_2","article-title":"Folklore medicinal plants used in liver disease: a review","volume":"12","author":"Naghdi N.","year":"2018","journal-title":"International Journal of Green Pharmacy"},{"key":"e_1_2_8_14_2","volume-title":"Traditional Medicine Strategy: 2014-2023","author":"Who","year":"2013"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.1.79"},{"key":"e_1_2_8_16_2","unstructured":"WHO Obesity And Overweight 2021 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-039200"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/35007508"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0535"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-11-200312020-00013"},{"key":"e_1_2_8_21_2","first-page":"195","article-title":"The historical development, efficacy and safety of very-low-calorie diets","volume":"5","author":"Howard A. 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