{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:20:08Z","timestamp":1790461208951,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondation Priv\u00e9e des HUG"},{"name":"Ligue pulmonaire genevoise"},{"name":"Migros"},{"name":"ResMed, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Medicine"],"published-print":{"date-parts":[[2023,1,31]]},"abstract":"<jats:p>Aim. It is known that children and adolescents with obesity are more prone to obstructive sleep apnea syndrome (OSAS) and that their lung function may show some disturbance. Literature is scarce about potential associations; therefore, we aimed to study the relationship between OSAS, lung function, and adiposity in a population of children suspected of OSAS. Material and Methods. We performed home respiratory polygraphy and spirometry in all subjects. The relationships between body mass index <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>z<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>-score (zBMI), polygraphy, and spirometry data were analyzed. Results. We recruited 81 subjects aged between 5 and 16 years, 63% being obese. 43.2% of subjects were diagnosed with OSAS (32.1% mild, 4.9% moderate, and 6.2% severe). We found no correlation between respiratory polygraphy and the zBMI. The mean spirometric value FEV1, FVC, and FEV1\/FVC ratio <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>z<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2019s were normal in all subjects, whereas FVC <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>z<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2019s and FEV1\/FVC ratio <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>z<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2019s were significantly positively related for obesity and negatively for normal weight (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). FEV1<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>z<\/k:mi>\n                     <\/k:math>\n                  <\/jats:inline-formula>\u2019s was inversely correlated to the percentage of analyzed time passed below 90% of SpO2 (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>r<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mo>\u2212<\/m:mo>\n                        <m:mn>0.224<\/m:mn>\n                        <m:mo>,<\/m:mo>\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.044<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>). All subjects with FEV1 (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>n<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>8<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>) and\/or FVC (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>n<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>9<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>) <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>z<\/s:mi>\n                     <\/s:math>\n                  <\/jats:inline-formula>\u2019s below the lower limit for normal (LLN) had an <jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mtext>AHI<\/u:mtext>\n                        <u:mo>\u2265<\/u:mo>\n                        <u:mn>1<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula> (FEV1: <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mi>p<\/w:mi>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>0.001<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>; FVC: <jats:inline-formula>\n                     <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <y:mi>p<\/y:mi>\n                        <y:mo>&lt;<\/y:mo>\n                        <y:mn>0.001<\/y:mn>\n                     <\/y:math>\n                  <\/jats:inline-formula>), especially subjects with normal weight (FEV1: <jats:inline-formula>\n                     <ab:math xmlns:ab=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\">\n                        <ab:mi>p<\/ab:mi>\n                        <ab:mo>=<\/ab:mo>\n                        <ab:mn>0.003<\/ab:mn>\n                     <\/ab:math>\n                  <\/jats:inline-formula>; FVC: <jats:inline-formula>\n                     <cb:math xmlns:cb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\">\n                        <cb:mi>p<\/cb:mi>\n                        <cb:mo>=<\/cb:mo>\n                        <cb:mn>0.010<\/cb:mn>\n                     <\/cb:math>\n                  <\/jats:inline-formula>). Conclusion. When comparing normal-weight children and adolescents with obesity, the prevalence of OSAS but not spirometric values was strongly related to BMI <jats:inline-formula>\n                     <eb:math xmlns:eb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\">\n                        <eb:mi>z<\/eb:mi>\n                     <\/eb:math>\n                  <\/jats:inline-formula>-score, probably because obesity engenders advanced puberty and an accelerated growth spurt. FEV1 was more frequently &lt;LLN in normal-weight children, while obese subjects presented low FEV1\/FVC ratio <jats:inline-formula>\n                     <gb:math xmlns:gb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M17\">\n                        <gb:mi>z<\/gb:mi>\n                     <\/gb:math>\n                  <\/jats:inline-formula>\u2019s and FEF25-75%<jats:inline-formula>\n                     <ib:math xmlns:ib=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M18\">\n                        <ib:mi>z<\/ib:mi>\n                     <\/ib:math>\n                  <\/jats:inline-formula>\u2019s. Moreover, all subjects with abnormal spirometric values were suffering from at least mild OSAS, again more frequently in normal-weight subjects.<\/jats:p>","DOI":"10.1155\/2023\/1532443","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:50:33Z","timestamp":1675212633000},"page":"1-7","source":"Crossref","is-referenced-by-count":2,"title":["Home Respiratory Polygraphy and Spirometry in Normal Weight and Children with Obesity Suspected for Obstructive Sleep Apnea Syndrome: Are There Any Associations?"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7530-1049","authenticated-orcid":true,"given":"Regula","family":"Corbelli","sequence":"first","affiliation":[{"name":"Pediatric Pulmonary Unit, Division of Pediatric Specialties, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8951-3149","authenticated-orcid":true,"given":"Constance","family":"Barazzone","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Unit, Division of Pediatric Specialties, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-0794","authenticated-orcid":true,"given":"Carole","family":"Grasset Salomon","sequence":"additional","affiliation":[{"name":"Pediatric Research Platform, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1841-0927","authenticated-orcid":true,"given":"Maurice","family":"Beghetti","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Unit, Division of Pediatric Specialties, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-4467","authenticated-orcid":true,"given":"Albane B. R.","family":"Maggio","sequence":"additional","affiliation":[{"name":"Pediatric Obesity Consultation, Division of Pediatric Specialties, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva, 1211 Geneva 14, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00385-2015"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-135MG"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.11.002"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1590\/S1679-45082014RW2691"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20854"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.07.010"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22915"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201311-403OC"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.4.361"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199603)21:3<176::AID-PPUL5>3.0.CO;2-O"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.03.024"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5630"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1959"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.11.1264"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02378.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2021.110635"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3392"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201212-2208LE"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02232.x"},{"key":"23","first-page":"5","article-title":"Lung volumes and forced ventilatory flows. 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