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Our objective is to enhance understanding of potential neurological side effects, inform clinical practice, and guide future research on the neurological implications of COVID\u201019 vaccination. <jats:italic>Methods<\/jats:italic>. In this systematic review, we conducted a comprehensive search in PubMed, Scopus, and Web of Science from January 2020 to April 2023, using terms related to COVID\u201019 vaccination and CNS MRI findings. We evaluated the quality of the study, extracted relevant data, and included 89 eligible studies that covered various vaccines, demographics of patients, symptoms, and MRI findings to provide a thorough understanding of SARS\u2010CoV\u20102 vaccination\u2010related CNS problems. <jats:italic>Results<\/jats:italic>. We investigated CNS MRI findings following COVID\u201019 vaccination across various vaccine types. Common diseases associated with post\u2010vaccination CNS MRI findings included cerebral venous sinus thrombosis (CVST), vaccine\u2010induced immune thrombotic thrombocytopenia (VITT), acute disseminated encephalomyelitis (ADEM), acute myelitis, autoimmune encephalitis (AE), and others. Patients presented with diverse onset symptoms and neurological manifestations. Abnormalities identified in CNS MRI findings included white matter (WM) hyperintensity. Our analysis offers a comprehensive overview of the current literature on post\u2010vaccination CNS MRI findings. <jats:italic>Discussion<\/jats:italic>. We highlight a range of post\u2010COVID\u201019 vaccination CNS MRI findings, including CVST, with a higher incidence in individuals receiving the ChAdOx1 (AstraZeneca) vaccine. Other notable observations include cases of ADEM, myelitis or transverse myelitis (TM), Guillain\u2013Barr\u00e9 syndrome (GBS), and acute encephalopathy following COVID\u201019 vaccination. The incidence of these neurological complications is extremely rare, and the benefits of vaccination outweigh the risks. The reviewed studies were primarily case reports or case series, and thus large\u2010scale epidemiological studies and controlled clinical trials are needed to better understand the underlying mechanisms and risk factors associated with these neurological complications following COVID\u201019 vaccination.<\/jats:p>","DOI":"10.1155\/2023\/1570830","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T18:35:07Z","timestamp":1688063707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Post\u2010COVID\u201019 Vaccination CNS Magnetic Resonance Imaging Findings: A Systematic 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