{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:54:08Z","timestamp":1747191248501,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:p>Introduction. Fatigue and orthostatic hypotension (OH) are common and disabling nonmotor symptoms (NMSs) of Parkinson\u2019s disease (PD), but none of the studies have reported on the longitudinal association between fatigue and OH. Methods. Drug-na\u00efve PD patients were recruited from a hospital-based cohort and evaluated with the Parkinson Fatigue Scale (PFS), head-up tilt test, Unified PD Rating Scale, Hoehn and Yahr stage, Montreal Cognitive Assessment, Scale for Outcomes in PD-Autonomic (SCOPA-AUT), Beck Depression Inventory (BDI), Beck Anxiety Inventory, PD Sleep Scale, and medications at the baseline and follow-up visits. Results. A total of 80 patients were included, and the mean ages were 66.6 and 63.8\u2009years in the fatigue and nonfatigue groups, respectively. The prevalence of fatigue was 17.5% (14\/80) at the baseline and follow-up (mean follow-up: 23.3\u2009\u00b1\u20099.9\u2009months). The prevalence of OH in the fatigue group was 57.1%, and it was significantly higher than that of the nonfatigue group. Six of the 14 patients (42.9%) in the fatigue group had persistent fatigue at the follow-up, and eight of them (57.1%) converted to the nonfatigue group. Logistic regression analysis demonstrated that the changes of BDI and the presence of OH at the baseline were the predictors for fatigue in drug-na\u00efve PD. Conclusion. Fatigue is a common NMS in PD but can vary depending on the disease course. OH and depression are the most relevant predictors for the development of fatigue in drug-na\u00efve PD. The present study suggests that the management of autonomic symptoms and depression might be helpful for managing fatigue in PD.<\/jats:p>","DOI":"10.1155\/2023\/1700893","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T17:50:24Z","timestamp":1675878624000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Orthostatic Hypotension Is a Predictor of Fatigue in Drug-Na\u00efve Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6415-2316","authenticated-orcid":true,"given":"Jong Hyeon","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"},{"name":"Neuroscience Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9145-6729","authenticated-orcid":true,"given":"Jin Whan","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"},{"name":"Neuroscience Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3350-5032","authenticated-orcid":true,"given":"Jinyoung","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"},{"name":"Neuroscience Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27461"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2021.03.018"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3233\/jpd-201919"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1201"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000144277.06917.cc"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13161"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.08.019"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14520"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.701906"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23744"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2016.12.2.172"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12343"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"14","article-title":"Diagnostic and statistical manual of mental disorders","volume-title":"A Companion to Criminal Justice, Mental Health and Risk","author":"C. 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