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This study is aimed at evaluating the effect of <jats:italic>P. dactylifera<\/jats:italic> seeds to cure Alzheimer\u2019s disease (AD). AD was induced in the rats with streptozotocin + aluminium chloride followed by treatment of methanolic extract of <jats:italic>P. dactylifera<\/jats:italic> seeds. The blood glucose levels were determined at regular intervals, which showed a prominent decrease in the extracts treated group. Behavior tests, including the Elevated Plus Maze (EPM) test and Morris Water Maze (MWM) test, were used to evaluate memory patterns in rats. The results indicated that extract\u2010treated rats significantly improved memory behavior compared to the diseased group. After dissection, the serum electrolytes, antioxidant enzymes, and choline esterase enzymes were measured in different organs. The serum parameters creatinine, urea, and bilirubin increased after extract treatment. Similarly, the level of antioxidant enzymes like peroxidases (POD), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and thiobarbituric acid reactive substance (TBARS) in the extract\u2010treated group showed improved results that were close to the normal control group. The enzyme (lipase, insulin, amylase, and acetylcholine) levels were found enhanced in extract groups as compared to diseased rats. High\u2010performance liquid chromatography (HPLC) was used to determine the level of dopamine and serotonin neurotransmitters, which were increased significantly for <jats:italic>P. dactylifera<\/jats:italic> seeds with values of 0.18\u2009<jats:italic>\u03bc<\/jats:italic>g\/mg tissue and 0.56\u2009<jats:italic>\u03bc<\/jats:italic>g\/mg tissue, respectively. Overall, results showed that <jats:italic>P. dactylifera<\/jats:italic> seeds proved to be quite efficient in improving the memory and behavior of treated rats. The antioxidants and enzymes were also increased; therefore, it may be a potential candidate for treating AD.<\/jats:p>","DOI":"10.1155\/2023\/1725638","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T06:05:12Z","timestamp":1673330712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of <i>Phoenix dactylifera<\/i> against Streptozotocin\u2010Aluminium Chloride Induced Alzheimer\u2019s Rats and Their In Silico Study"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8008-4595","authenticated-orcid":false,"given":"Hammad","family":"Ismail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad Bin","family":"Ayub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Umar","family":"Ijaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samra","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-0532","authenticated-orcid":false,"given":"Muhammad Zeeshan","family":"Bhatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik Mumtaz","family":"Taqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-7428","authenticated-orcid":false,"given":"Erum","family":"Dilshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadaf","family":"Anwaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaber El-Saber","family":"Batiha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Aggad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah M.","family":"Yousef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel De","family":"Waard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.11.014"},{"key":"e_1_2_8_2_2","first-page":"30","article-title":"Diabetes and its predictive role in the incidence of Alzheimer\u2032s disease","volume":"23","author":"Madmoli M.","year":"2019","journal-title":"Medical Science"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_8_4_2","first-page":"172","article-title":"Improvement diagnosis of diabetes using a combination of sugeno fuzzy inference systems and firefly algorithms","volume":"15","author":"Shirali M.","year":"2017","journal-title":"Iranian Journal of Diabetes and Metabolism"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.31407\/ijees8324"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/11597760-000000000-00000"},{"key":"e_1_2_8_7_2","article-title":"Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis","volume":"10","author":"de la Monte S. 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