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Ginseng flowers (GFs), the nonmedicinal parts, are usually removed every autumn, in which components are generally believed to stay unchanged with the increasing cultivation age. Recently, few documents were reported on the variation of volatile organic compounds (VOCs) and other components about ginseng flowers. This study had an insight into the variation of the chemical constituents with the cultivation ages through the comparison of the volatile organic compounds, gross ginsenosides, crude polysaccharide, and gross proteins of ginseng flowers from 3-, 4-, 5-, and 6-yr-old (GF3, GF4, GF5, and GF6) which were conducted by headspace solid-phase microextraction-gas chromatography-triple quadrupole mass spectrometry (HS-SPME-GC-QQQ\/MS) and spectroscopic analysis combined with multivariate statistical analysis, including one-way ANOVA analysis and T test. The results indicated that the crude polysaccharide contents raised significantly depending on cultivation age except 6-yr-old, whereas the gross ginsenosides and the gross protein content were indistinctive. According to the peak intensity of determined VOCs, the contents of most differential compounds arranged in an order from high to low are GF3, GF4, GF5, and GF6, such as the compounds 2\u201315, 17\u201319, 22, and 25\u201326, therefore, they can be inferred that they are important markers to identify the age of GFs. 461 common differential compounds were gained and 26 common volatile organic compounds were identified with RSI &gt;800 and RI and RIx no more than 30, including alcohols (such as 11, 12, and 15), sesquiterpenes (such as 2, 3, and 4), esters (such as 1 and 26), naphthalene and naphthol (such as 7 and 20), which had potential effects on curing Alzheimer\u2019s disease, inflammatory diseases, and prostate cancer based on network pharmacology analysis. This paper firstly revealed the variation rules of constitutions of GFs, which may provide a reference for the harvest and making rational application.<\/jats:p>","DOI":"10.1155\/2023\/1771563","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T22:35:08Z","timestamp":1680647708000},"page":"1-12","source":"Crossref","is-referenced-by-count":4,"title":["Comparative Study on Chemical Constituents of Ginseng Flowers with Four Consecutive Cultivation Age"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-1871","authenticated-orcid":true,"given":"Lian-Yun","family":"Du","sequence":"first","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-9079","authenticated-orcid":true,"given":"Hui-E.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yan","family":"Han","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1253-9674","authenticated-orcid":true,"given":"Ping","family":"Ye","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-3520","authenticated-orcid":true,"given":"Xiang-Ru","family":"Meng","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-3391","authenticated-orcid":true,"given":"Yan-Long","family":"Shen","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Bao","family":"Chen","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1169-9924","authenticated-orcid":true,"given":"Mei-Ling","family":"Fan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130117, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-7715","authenticated-orcid":true,"given":"En-Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"3","key":"1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jgr.2014.03.001","article-title":"A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases","volume":"38","author":"C. 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