{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:36:44Z","timestamp":1788817004541,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Krembil-Rossy Chair"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-173540"],"award-info":[{"award-number":["PJT-173540"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ontario Research Fund"},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs Program","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005155","name":"Azrieli Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["888692"],"award-info":[{"award-number":["888692"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012479","name":"Weston Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF-007878"],"award-info":[{"award-number":["MJFF-007878"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Imaging"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n                    Synaptic density in the central nervous system can be measured in vivo using PET with [\n                    <jats:sup>18<\/jats:sup>\n                    F]SynVesT-1. While [\n                    <jats:sup>18<\/jats:sup>\n                    F]SynVesT-1 has been proven to be a powerful radiopharmaceutical for PET imaging of neurodegenerative disorders such as Parkinson\u2019s disease (PD), its currently validated acquisition and quantification protocols are invasive and technically challenging in these populations due to the arterial sampling and relatively long scanning times. The objectives of this work were to evaluate a noninvasive (reference tissue) quantification method for [\n                    <jats:sup>18<\/jats:sup>\n                    F]SynVesT-1 in PD patients and to determine the minimum scan time necessary for accurate quantification. [\n                    <jats:sup>18<\/jats:sup>\n                    F]SynVesT-1 PET scans were acquired in 5 patients with PD and 3 healthy control subjects for 120\u2009min with arterial blood sampling. Quantification was performed using the one-tissue compartment model (1TCM) with arterial input function, as well as with the simplified reference tissue model (SRTM) to estimate binding potential ([Formula: see text]) using centrum semiovale (CS) as a reference region. The SRTM2 method was used with [Formula: see text] fixed to either a sample average value (0.037\u2009min\n                    <jats:sup>-1<\/jats:sup>\n                    ) or a value estimated first through coupled fitting across regions for each participant. Direct SRTM estimation and the Logan reference region graphical method were also evaluated. There were no significant group differences in CS volume, radiotracer uptake, or efflux ([Formula: see text]). Each fitting method produced [Formula: see text] estimates in close agreement with those derived from the 1TCM (subject [Formula: see text], [Formula: see text]), with no difference in bias between the control and PD groups. With SRTM2, [Formula: see text] estimates from truncated scan data as short as 80\u2009min produced values in excellent agreement with the data from the full 120\u2009min scans ([Formula: see text]). While these are preliminary results from a small sample of patients with PD ([Formula: see text]), this work suggests that accurate synaptic density quantification may be performed without blood sampling and with scan time under 90 minutes. If further validated, these simplified procedures for [\n                    <jats:sup>18<\/jats:sup>\n                    F]SynVesT-1 PET quantification can facilitate its application as a clinical research imaging technology and allow for larger study samples and include a broader scope of patients including those with neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1155\/2023\/1855985","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T20:05:06Z","timestamp":1691784306000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Preliminary Assessment of Reference Region Quantification and Reduced Scanning Times for [\n                    <sup>18<\/sup>\n                    F]SynVesT-1 PET in Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-6943","authenticated-orcid":false,"given":"Kelly","family":"Smart","sequence":"first","affiliation":[{"name":"Brain Health Imaging CentreCentre for Addiction and Mental Health250 College St.TorontoONCanadaM5T 1R8"},{"name":"Department of PsychiatryUniversity of Toronto250 College St.TorontoONCanadaM5T 1R8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Uribe","sequence":"additional","affiliation":[{"name":"Brain Health Imaging CentreCentre for Addiction and Mental Health250 College St.TorontoONCanadaM5T 1R8"},{"name":"Unitat de Psicologia MedicaDepartament de MedicinaInstitute of NeuroscienceUniversitat de BarcelonaBarcelonaSpain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0626-9310","authenticated-orcid":false,"given":"Kimberly L.","family":"Desmond","sequence":"additional","affiliation":[{"name":"Brain Health Imaging CentreCentre for Addiction and Mental Health250 College St.TorontoONCanadaM5T 1R8"},{"name":"Department of PsychiatryUniversity of Toronto250 College St.TorontoONCanadaM5T 1R8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Martin","sequence":"additional","affiliation":[{"name":"Brain Health Imaging CentreCentre for Addiction and Mental Health250 College St.TorontoONCanadaM5T 1R8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Vasdev","sequence":"additional","affiliation":[{"name":"Brain Health Imaging CentreCentre for Addiction and Mental Health250 College St.TorontoONCanadaM5T 1R8"},{"name":"Department of PsychiatryUniversity of Toronto250 College St.TorontoONCanadaM5T 1R8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7779-0974","authenticated-orcid":false,"given":"Antonio P.","family":"Strafella","sequence":"additional","affiliation":[{"name":"Brain Health Imaging CentreCentre for Addiction and Mental Health250 College St.TorontoONCanadaM5T 1R8"},{"name":"Edmond J. Safra Parkinson Disease ProgramNeurology DivisionToronto Western Hospital & Krembil Brain InstituteUniversity Health NetworkUniversity of Toronto399 Bathurst StreetTorontoONCanadaM5T 2S8"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"bibr1-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2019.02.001"},{"key":"bibr2-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12097"},{"key":"bibr3-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf6667"},{"key":"bibr4-2023_1855985","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091005"},{"key":"bibr5-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.13"},{"key":"bibr6-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.1312"},{"key":"bibr7-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25682"},{"key":"bibr8-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28216"},{"key":"bibr9-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28064"},{"key":"bibr10-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00526"},{"key":"bibr11-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-05149-3"},{"key":"bibr12-2023_1855985","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.249144"},{"key":"bibr13-2023_1855985","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.2967\/jnumed.121.262430","volume":"63","author":"Naganawa M.","year":"2022","journal-title":"Journal of Nuclear Medicine"},{"key":"bibr14-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19879230"},{"key":"bibr15-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-018-4119-8"},{"key":"bibr16-2023_1855985","unstructured":"Desmond K., Lindberg A., Garcia A., Tong J., Harkness M., Dobrota E., Smart K., Uribe C., Meyer J., Houle S., Strafella A., Li S., Huang Y., Vasdev N. First-in-human PET imaging of [18F]SDM-4MP3: A cautionary tale Molecular Imaging, in press"},{"key":"bibr17-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10123"},{"key":"bibr18-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189"},{"key":"bibr19-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600830718"},{"key":"bibr20-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.180"},{"key":"bibr21-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.34"},{"key":"bibr22-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000038000.34930.4E"},{"key":"bibr23-2023_1855985","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199609000-00008"}],"container-title":["Molecular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1155\/2023\/1855985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1155\/2023\/1855985","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1155\/2023\/1855985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:53:20Z","timestamp":1777614800000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1155\/2023\/1855985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":23,"alternative-id":["10.1155\/2023\/1855985"],"URL":"https:\/\/doi.org\/10.1155\/2023\/1855985","relation":{},"ISSN":["1535-3508","1536-0121"],"issn-type":[{"value":"1535-3508","type":"print"},{"value":"1536-0121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"article-number":"1855985"}}