{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T17:26:48Z","timestamp":1749835608871,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2023,3,6]]},"abstract":"<jats:p>Background. Limited data exist regarding the association between the quality of life (QoL) and clinical outcomes following transcatheter mitral valve repair (TMVr). We aimed to evaluate the prognostic significance of QoL assessment following TMVr and to characterize those who had procedural success, yet reported a low Kansas City Cardiomyopathy Questionnaire (KCCQ-12) score. Methods. We reported the experience of Cedars-Sinai Medical Center patients between 2013 and 2020. Patients were allocated into four groups according to the 30-day KCCQ: &lt;25, 25\u201349, 50\u201374, and \u226575. Primary outcome included 1-year all-cause death or heart failure (HF) hospitalizations. We also examined the association between QoL and the primary outcome in those with procedural success. Results. A total of 555 patients were included in our analysis, median follow-up of 650\u2009days (IQR 243\u20131113). The lower KCCQ groups had a higher prevalence of functional mitral regurgitation (65%, 60%, 56%, and 43%, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), as well as a higher Society of Thoracic Surgeon (STS) score. These groups had a significantly higher occurrence of 1-year all-cause death or HF hospitalizations in a stepwise fashion (40%, 22%, 16%, and 10%, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Multivariable Cox regression analysis revealed 30-day KCCQ as the strongest predictor of the 1-year primary outcome (HR 0.98, 95%CI (0.97\u20130.99), <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.006<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Approximately a quarter of patients with procedural success had a low KCCQ score. These patients had a higher rate of the combined 1-year outcome regardless of procedural success or failure. Conclusion. QoL following TMVr is a powerful prognostic factor. KCCQ assessment is an important indicator for identifying patients prone to adverse outcomes even after procedural success.<\/jats:p>","DOI":"10.1155\/2023\/1977911","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T16:50:15Z","timestamp":1678121415000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Quality of Life, Procedural Success, and Clinical Outcomes following Transcatheter Mitral Valve Repair"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3349-7298","authenticated-orcid":true,"given":"Sharon Shalom","family":"Natanzon","sequence":"first","affiliation":[{"name":"Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Koseki","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA"},{"name":"Department of Cardiovascular Medicine, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danon","family":"Kaewkes","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA"},{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-8276","authenticated-orcid":true,"given":"Ofir","family":"Koren","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA"},{"name":"Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Patel","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-2662","authenticated-orcid":true,"given":"Tarun","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Makkar","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.120.008998"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1806640"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1009355"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.03.002"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(00)00531-3"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.02.006"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.113.007477"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.3359"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/circoutcomes.120.007187"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312001"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312002"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.5971"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.11.006"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1805374"},{"issue":"6","key":"15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jacc.2012.03.075","article-title":"Health-related quality of life after transcatheter or surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results from the PARTNER (Placement of AoRTic TraNscathetER Valve) Trial (Cohort A)","volume":"60","author":"M. 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