{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:10:56Z","timestamp":1778314256666,"version":"3.51.4"},"reference-count":121,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160148"],"award-info":[{"award-number":["82160148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CYXZ2021-16"],"award-info":[{"award-number":["CYXZ2021-16"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CYXZ2022-41"],"award-info":[{"award-number":["CYXZ2022-41"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital","award":["82160148"],"award-info":[{"award-number":["82160148"]}]},{"name":"Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital","award":["CYXZ2021-16"],"award-info":[{"award-number":["CYXZ2021-16"]}]},{"name":"Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital","award":["CYXZ2022-41"],"award-info":[{"award-number":["CYXZ2022-41"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2023,11,13]]},"abstract":"<jats:p>Chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) is one of the most common diseases of the male urological system while the etiology and treatment of CP\/CPPS remain a thorny issue. Cumulative research suggested a potentially important role of glial cells in CP\/CPPS. This narrative review retrospected literature and grasped the research process about glial cells and CP\/CPPS. Three types of glial cells showed a crucial connection with general pain and psychosocial symptoms. Microglia might also be involved in lower urinary tract symptoms. Only microglia and astrocytes have been studied in the animal model of CP\/CPPS. Activated microglia and reactive astrocytes were found to be involved in both pain and psychosocial symptoms of CP\/CPPS. The possible mechanism might be to mediate the production of some inflammatory mediators and their interaction with neurons. Glial cells provide a new insight to understand the cause of complex symptoms of CP\/CPPS and might become a novel target to develop new treatment options. However, the activation and action mechanism of glial cells in CP\/CPPS needs to be further explored.<\/jats:p>","DOI":"10.1155\/2023\/2061632","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T20:35:10Z","timestamp":1699907710000},"page":"1-12","source":"Crossref","is-referenced-by-count":10,"title":["Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis\/Chronic Pelvic Pain Syndrome"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-1115","authenticated-orcid":true,"given":"Yongfeng","family":"Lao","sequence":"first","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"Department of Urology, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zewen","family":"Li","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"Department of Urology, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Bai","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijia","family":"Li","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"Department of Urology, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"Department of Urology, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingchao","family":"Li","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"Department of Urology, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4919-8164","authenticated-orcid":true,"given":"Zhilong","family":"Dong","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"Department of Urology, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13101"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.08.016"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1177\/20494637211015265"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.7326\/m21-1814"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1913"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14988"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1177\/1557988320903200"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24343"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.1028653"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120240"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(04)00069-8"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1202529"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056293"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000527"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052358"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.013"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1383-5"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013053"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2016"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24140"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3390\/cells8020184"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020388"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-9913-8_5"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.09.008"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020479"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8924"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-2236(00)01854-3"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2002"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.3mr0520-695r"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1722"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.04.013"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1097\/hrp.0000000000000060"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-019-00723-2"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1584-3"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22891"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020537"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22408"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-093019-110159"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1435s104"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525528113"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-021-01159-3"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.08.062"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(98)00583-3"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135600"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1038\/nature10959"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10205"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.08.013"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22648"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1242\/dev.004895"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.01.005"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.11.030"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020453"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.04.002"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300313110"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3155"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-011-9288-x"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3792-03.2004"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10248"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.01.002"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1177\/039463200802100108"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24040"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1870"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22263"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu140"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2017"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-267146"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1021-4"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2019.5.02"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.146.5.1490"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201504106"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-3806(01)00128-6"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20747"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.7710"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1137-14.2014"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2014.994506"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.05.044"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.05.053"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-020-1815-6"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002148"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2011-111097"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-15"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12080"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.03.032"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507901102"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.44"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.06.008"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.2174\/187152707780619326"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1016\/s0920-9964(03)00181-6"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)14289-4"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-3223(02)01404-x"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.08.009"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.06.038"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1038\/nature13152"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3743"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1016\/s0090-4295(01)01470-4"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1590\/s1677-5538.ibju.2013.02.17"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.02.025"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.2147\/ndt.s211288"},{"issue":"4","key":"99","first-page":"342","article-title":"[Activation of astrocytes effects changes of substance P in cornu dorsal medullae spinalis in chronic prostatitis rats]","volume":"13","author":"S. W. Zhang","year":"2007","journal-title":"Zhonghua Nan ke Xue"},{"issue":"11","key":"100","first-page":"1021","article-title":"[Correlation between activation of L5-S2 spinal cord astrocytes and effect of substance P in chronic prostatitis pain]","volume":"15","author":"H. Zhang","year":"2009","journal-title":"Zhonghua Nan ke Xue"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.2147\/jpr.s321119"},{"issue":"5","key":"102","first-page":"403","article-title":"[Infiltration of Th1 and Th17 cells into the L5-S2 spinal cord in CP\/CPPS rats and its central sensitization mechanism]","volume":"27","author":"Q. Z. Yu","year":"2021","journal-title":"Zhonghua Nan ke Xue"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001954"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-022-01141-6"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0033-9"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02125-y"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.736688"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2868"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-008-8051-6"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.3109\/00365599.2012.669403"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2017.04.011"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.109806"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-1756-9_7"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.01.025"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-328x(98)00040-0"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.17.3073"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.820127"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02562-3"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.902372"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq2923"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15149"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2023\/2061632.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2023\/2061632.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2023\/2061632.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T20:35:17Z","timestamp":1699907717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/prm\/2023\/2061632\/"}},"subtitle":[],"editor":[{"given":"Alessandro","family":"Vittori","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":121,"alternative-id":["2061632","2061632"],"URL":"https:\/\/doi.org\/10.1155\/2023\/2061632","relation":{},"ISSN":["1918-1523","1203-6765"],"issn-type":[{"value":"1918-1523","type":"electronic"},{"value":"1203-6765","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,13]]}}}