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The intricate interaction of the human defense system, hereditary predisposition, and specific bitterness elements is more likely to be the pathogenesis of dengue. There are presently no viable treatments for dengue. Synthetic drugs which are used against this ailment also show major side effects. There must be a deeper understanding of the underlying mechanism generating severe symptoms to develop auguring markers, cutting\u2010edge diagnostics, and treatments and finally a well\u2010rounded and secure antiserum. Hence, the aim is to search for safer and more potent drugs derived from plants. Plants or herbs are mainly targeting replication or its enzyme or specific stereotypes, though an exact mechanism of phytoconstituents interfering with the viral replication is still undiscovered. The present attempt provided the update with the objective to bringing up forward pathophysiological eventualities involved in dengue virus along with the naturally derived treatment relevant to provide the impregnable therapy by evading the noxious symptoms for dengue fever. <jats:italic>Governor\u2019s plum<\/jats:italic>, <jats:italic>Cryptocarya chartacea<\/jats:italic>, magnolia berry, and Chinese ginger are such plants exhibiting many effective phytoconstituents against DENV and can be further explored for novel drug discovery by medicinal scientists.<\/jats:p>","DOI":"10.1155\/2023\/2236210","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T13:38:19Z","timestamp":1676036299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Current Landscape of Bioactive Molecules against DENV: A Systematic 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