{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:01:51Z","timestamp":1740157311184,"version":"3.37.3"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005844","name":"Universitas Diponegoro","doi-asserted-by":"publisher","award":["3066\/UN.7.5.4.2\/PP\/2022"],"award-info":[{"award-number":["3066\/UN.7.5.4.2\/PP\/2022"]}],"id":[{"id":"10.13039\/501100005844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2023,9,14]]},"abstract":"<jats:p>Liver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites. Hepatogomax enteral formula was developed, which contains brain-chain amino acids (BCAAs) and middle-chain triglycerides (MCTs), which could repair liver tissue damage, improve the inflammatory status, and modulate SCFA in liver damage. The study aimed to determine the effect of hepatogomax on liver tissue repair, inflammation (TNF-\u03b1 and IL-6), and SCFA levels in thioacetamide (TAA)-induced rats. The induction of TAA causes liver steatosis, increasing TNF-\u03b1 and IL-6, and decreasing SCFA levels. Hepatogomax at a dose of 14.6\u2009g\/200\u2009gBW significantly reduces TNF-\u03b1 and IL-6 levels and increases SCFA levels (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.05). The number of steatosis between groups P2 and P3 was lower as compared to a group of negative control [K2] (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.05). Hepatogomax, in a dose-dependent manner, may repair liver tissue and improve inflammatory response and SCFA levels in TAA-induced rats.<\/jats:p>","DOI":"10.1155\/2023\/2313503","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:35:19Z","timestamp":1694730919000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4235-8564","authenticated-orcid":true,"given":"Hery D.","family":"Purnomo","sequence":"first","affiliation":[{"name":"Division of Gastroentero-Hepatology, Department of Internal Medical, Dr Kariadi Hospital, Faculty of Medicine, Diponegoro University, Semarang 50275, 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R.","family":"Solichin","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta 55281, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choirun","family":"Nissa","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang 50275, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriyan","family":"Pramono","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang 50275, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Endang","family":"Mahati","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapy, Faculty of Medicine, Diponegoro University, Semarang 50275, 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