{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:21:22Z","timestamp":1772551282656,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangsu Province Capability Improvement Project","award":["CXZX202231"],"award-info":[{"award-number":["CXZX202231"]}]},{"name":"Jiangsu Province Capability Improvement Project","award":["2022116"],"award-info":[{"award-number":["2022116"]}]},{"name":"Jiangsu Province Capability Improvement Project","award":["SKY2022118"],"award-info":[{"award-number":["SKY2022118"]}]},{"name":"Jiangsu Province Capability Improvement Project","award":["82202898"],"award-info":[{"award-number":["82202898"]}]},{"name":"Jiangsu Province Capability Improvement Project","award":["BXQN202108"],"award-info":[{"award-number":["BXQN202108"]}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["CXZX202231"],"award-info":[{"award-number":["CXZX202231"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["2022116"],"award-info":[{"award-number":["2022116"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["SKY2022118"],"award-info":[{"award-number":["SKY2022118"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["82202898"],"award-info":[{"award-number":["82202898"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["BXQN202108"],"award-info":[{"award-number":["BXQN202108"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CXZX202231"],"award-info":[{"award-number":["CXZX202231"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022116"],"award-info":[{"award-number":["2022116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SKY2022118"],"award-info":[{"award-number":["SKY2022118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202898"],"award-info":[{"award-number":["82202898"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BXQN202108"],"award-info":[{"award-number":["BXQN202108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007824","name":"Soochow University","doi-asserted-by":"publisher","award":["CXZX202231"],"award-info":[{"award-number":["CXZX202231"]}],"id":[{"id":"10.13039\/501100007824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007824","name":"Soochow University","doi-asserted-by":"publisher","award":["2022116"],"award-info":[{"award-number":["2022116"]}],"id":[{"id":"10.13039\/501100007824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007824","name":"Soochow University","doi-asserted-by":"publisher","award":["SKY2022118"],"award-info":[{"award-number":["SKY2022118"]}],"id":[{"id":"10.13039\/501100007824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007824","name":"Soochow University","doi-asserted-by":"publisher","award":["82202898"],"award-info":[{"award-number":["82202898"]}],"id":[{"id":"10.13039\/501100007824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007824","name":"Soochow University","doi-asserted-by":"publisher","award":["BXQN202108"],"award-info":[{"award-number":["BXQN202108"]}],"id":[{"id":"10.13039\/501100007824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:p>Objective. To explore the relationship between circulating IGFBP-3, IL-6, and bone mineral density and the potential diagnostic role of circulating IGFBP-3 and IL-6 in postmenopausal women with osteoporosis. Methods. Eighty-five postmenopausal women at Soochow University\u2019s First Affiliated Hospital, Osteoporosis and Menopause Clinics, were recruited. Forty-five of 85 women were diagnosed with osteoporosis. Circulating IL-6, PTH, 1,25(OH)2D3, osteocalcin (OST), IGF-1, IGFBP-3, and bone mineral density (BMD) of the lumbar spine (LS) and femoral neck (FN) were measured in 40 ordinary and 45 osteoporotic women. A simple regression analysis calculated the correlation between age, BMD, IL-6, and IGFBP-3. Multiple stepwise regression analyses were conducted to determine which variables were independently related to BMD. The potential role of IGFBP-3 and IL-6 in the diagnosis of postmenopausal osteoporosis was predicted using the area under the receiver operating characteristic curve (ROC, AUC). Results. Age, years since menopause, and circulating IL-6, PTH, and IGFBP-3 were significantly higher in the osteoporosis group compared to the normal group. Osteoporotic women had substantially lower BMDs of the LS and FN than normal women. Age-related increases were found for IGFBP-3 and IL-6, whereas age-related decreases were observed for LS\/FN BMD. IGFBP-3 and IL-6 were both negatively correlated with LS and FN BMD. Stepwise multiple regression analysis showed that IGFBP-3 and IL-6 were strong predictors of BMD in postmenopausal women. AUC cut-off values (IGFBP-3: 3.65, IL-6: 0.205) were best evaluated for the diagnosis of postmenopausal women with osteoporosis, and the AUC for circulating IGFBP-3 and IL-6 were 0.706 (95% CI 0.594\u20130.818) and 0.685 (95% CI 0.571\u20130.798), respectively. Conclusion. In this cross-sectional study of postmenopausal women, IGFBP-3 and IL-6 were negatively related to BMD. Circulating IGFBP-3 and IL-6 might be essential predictors of postmenopausal osteoporosis and can help predict osteoporotic fracture.<\/jats:p>","DOI":"10.1155\/2023\/2613766","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T19:50:29Z","timestamp":1680292229000},"page":"1-6","source":"Crossref","is-referenced-by-count":21,"title":["Circulating IGFBP-3 and Interleukin 6 as Predictors of Osteoporosis in Postmenopausal Women: A Cross-Sectional Study"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3163-2062","authenticated-orcid":true,"given":"Xiu","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital, Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Affiliated Huai\u2019an Hospital of Xuzhou Medical University and Second People\u2019s Hospital of Huaian, Huai\u2019an 223001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"},{"name":"National Regional Center for Trauma Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1496-9141","authenticated-orcid":true,"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"},{"name":"National Regional Center for Trauma Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8250-4541","authenticated-orcid":true,"given":"Shouqian","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"},{"name":"National Regional Center for Trauma Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"9","key":"1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/GME.0000000000001831","article-title":"Management of osteoporosis in postmenopausal women: the 2021 position statement of the North American Menopause Society","volume":"28","author":"J. Blake","year":"2021","journal-title":"Menopause"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308755110"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1513724"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/0272684X20936833"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1055\/a-0859-4285"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-018-0063-8"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13588"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(96)01814-3"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.11.065"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209757"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(96)01080-8"},{"issue":"5","key":"12","first-page":"2032","article-title":"Serum interleukin 6 is a major predictor of bone loss in women specific to the first decade past menopause","volume":"86","author":"C. Scheidt-Nave","year":"2001","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"8","key":"13","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"The diagnosis of osteoporosis","volume":"9","author":"J. A. Kanis","year":"1994","journal-title":"Journal of Bone and Mineral Research"},{"issue":"4","key":"14","doi-asserted-by":"crossref","first-page":"840","DOI":"10.12669\/pjms.304.4624","article-title":"Effect of moderate aerobic training on bone metabolism indices among adult humans","volume":"30","author":"A. H. Alghadir","year":"2014","journal-title":"Pakistan Journal of Medical Sciences"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S100566"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-5-1292"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00867.x"},{"issue":"6","key":"18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1530\/eje.0.1380633","article-title":"Age-dependent changes in body composition in postmenopausal Japanese women: relationship to growth hormone secretion as well as serum levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3","volume":"138","author":"T. Sugimoto","year":"1998","journal-title":"European Journal of Endocrinology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011524"},{"issue":"8","key":"20","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jbmr.5650110802","article-title":"Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis","volume":"11","author":"R. Pacifici","year":"1996","journal-title":"Journal of Bone and Mineral Research"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.7.4334"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.5.1347"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/16852"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2019.06.002"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0028"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-018-0698-2"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2015.06.003"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153810"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1658-y"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2023\/2613766.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2023\/2613766.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2023\/2613766.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T19:50:38Z","timestamp":1680292238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2023\/2613766\/"}},"subtitle":[],"editor":[{"given":"Sidong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":29,"alternative-id":["2613766","2613766"],"URL":"https:\/\/doi.org\/10.1155\/2023\/2613766","relation":{},"ISSN":["1466-1861","0962-9351"],"issn-type":[{"value":"1466-1861","type":"electronic"},{"value":"0962-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,31]]}}}