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In this study, a TGEV strain was isolated from the small intestine of diarrhea piglets in Sichuan Province, China, and designated SC2021. The complete genomic sequence of TGEV SC2021 was 28561\u2009bp, revealing a new natural deletion TGEV strain. Based on phylogenetic analyses, TGEV SC2021 belonged to the Miller cluster and was closely related to CN strains. The newborn piglets orally challenged with TGEV SC2021 showed typical watery diarrhea. In addition, macro and micropathological changes in the lungs and intestines were observed. In conclusion, we isolated a new natural deletion virus strain and confirmed that the virus strain has high pathogenicity in newborn piglets. Moreover, macroscopic and microscopic lesions were observed in the lungs and intestines of all TGEV SC2021-infected piglets. In summary, we isolated a new natural deletion TGEV strain and demonstrated that the natural deletion strain showed high pathogenicity in newborn piglets. These data enrich the diversity of TGEV strains and help us to understand the genetic evolution and molecular pathogenesis of TGEV.<\/jats:p>","DOI":"10.1155\/2023\/2652850","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T23:35:08Z","timestamp":1677886508000},"page":"1-13","source":"Crossref","is-referenced-by-count":5,"title":["Characterization and Evaluation of the Pathogenicity of a Natural Gene-Deleted Transmissible Gastroenteritis Virus in China"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9554-6927","authenticated-orcid":true,"given":"Lei","family":"Xu","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Key Laboratory of Animal Diseases and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5249-9530","authenticated-orcid":true,"given":"Hong-bo","family":"Dai","sequence":"additional","affiliation":[{"name":"Veterinary Biologicals Engineering and Technology Research Center of Sichuan Province, Animtech Bioengineering Co. 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