{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:39:46Z","timestamp":1777473586093,"version":"3.51.4"},"reference-count":97,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. This study is aimed at establishing phenolic compound profile and assessing the possible antiulcer activities of aqueous extracts of some staple plant foods from the West and North\u2010West regions of Cameroon against chronic gastric ulcer models in rats. <jats:italic>Materials and Methods<\/jats:italic>. Phenolic constituents of extracts were evaluated using HPLC\u2010DAD. Aqueous extracts of <jats:italic>Corchorus olitorius<\/jats:italic>, <jats:italic>Solanum nigrum<\/jats:italic>, <jats:italic>Vigna unguiculata<\/jats:italic>, <jats:italic>Triumfetta pentandra<\/jats:italic>, \u201cnkui\u201d spices, and \u201cyellow soup\u201d spices were tested at two doses (200 and 400\u2009mg\/kg). After treatments, animals were sacrificed, healing percentage and antioxidant status (catalase, superoxide dismutase, and glutathione peroxidase) were evaluated, and histological examination of gastric mucosa was realized. <jats:italic>Results<\/jats:italic>. HPLC\u2010DAD revealed that p\u2010hydroxybenzoic and protocatechuic acids were the phenolic compound present in all extracts. Oral administration of extracts (200 and 400\u2009mg\/kg) significantly reduced ulcer surface value and significantly increased mucus production compared to the control groups (<jats:italic>p<\/jats:italic> &lt; 0.05). Histological study supported the observed healing activity of different extracts characterized by a reduced inflammatory response. Moreover, administration of aqueous extracts increased the activity of antioxidant enzymes. <jats:italic>Conclusion<\/jats:italic>. This study revealed that aqueous extracts of <jats:italic>Solanum nigrum<\/jats:italic>, <jats:italic>Corchorus olitorius<\/jats:italic>, <jats:italic>Vigna unguiculata<\/jats:italic>, <jats:italic>Triumfetta pentandra<\/jats:italic>, \u201cyellow soup\u201d spices, and \u201cnkui\u201d spices possess healing antiulcer effects against models of gastric ulcers. The antiulcer mechanisms involved may include increase of gastric mucus production and improvement of the antioxidant activity of gastric tissue. These activities may be due to the phenolic compounds identified in the extracts, especially p\u2010hydroxybenzoic and protocatechuic acids present in all extracts and with known antioxidant, cytoprotective, and healing properties. However, all the diets may promote the healing process of chronic ulcers caused by excessive alcohol consumption\/stress.<\/jats:p>","DOI":"10.1155\/2023\/2657278","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T01:20:14Z","timestamp":1673313614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North\u2010West, Adamawa, and West Regions of Cameroon"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-6672","authenticated-orcid":false,"given":"Hauberline Domegne","family":"Mikwangock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6683-3337","authenticated-orcid":false,"given":"Alfred Ngenge","family":"Tamfu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-720X","authenticated-orcid":false,"given":"Andr\u00e9 Perfusion","family":"Amang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-1939","authenticated-orcid":false,"given":"Gael Tchokomeni","family":"Siwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-4338","authenticated-orcid":false,"given":"Christophe","family":"Mezui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-6528","authenticated-orcid":false,"given":"Selcuk","family":"Kucukaydin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enonchong George","family":"Enow-Orock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-1412","authenticated-orcid":false,"given":"Paul Vernyuy","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"e_1_2_10_1_2","unstructured":"Publication 2014 14 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-5412(12)70281-0"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.507"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i18.5283"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.1.121"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13394"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicines7050026"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2020.110150"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.03.023"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.84437"},{"key":"e_1_2_10_11_2","first-page":"11","article-title":"Data on ethnonutritional and physico-chemical characteristics of leafy vegetables consumed in the Adamawa savana (Cameroon)","volume":"22","author":"Tchiegang C.","year":"2004","journal-title":"Tropicultura"},{"key":"e_1_2_10_12_2","first-page":"193","article-title":"Chemical composition of spices used in the preparation of nah-poh and \u2018nkui\u2019 from Western Cameroon","volume":"4","author":"Tchiegang C.","year":"2005","journal-title":"Tropicultura"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.20959\/wjpps20225-21861"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-4337.2011.00156.x"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.9082"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.04.010"},{"key":"e_1_2_10_17_2","article-title":"Effet cytoprotecteur de l\u2019extrait aqueux des racines de Dorstenia psilurus sur l\u2019ulc\u00e8re gastrique chez les rats m\u00e2les de la souche Wistar","volume":"12","author":"Kamguia H. 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