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An absence of acute toxicity was observed. Menthofuran delayed gastric emptying at oral doses of 25, 50, and 100\u2009mg\/kg in the experimental model of phenol red, as well as it reduced the intestinal transit at oral doses of 50 and 100\u2009mg\/kg. Interestingly, a scopolamine\u2010similar hypokinetic effect was observed for menthofuran. In the experimental model of castor oil\u2010induced intestinal hypermotility, menthofuran (50 and 100\u2009mg\/kg) reduced the number of loose stools as observed for the normal group. Additionally, menthofuran induced a marked concentration\u2010dependent relaxation in rat ileum segments precontracted with KCl (EC<jats:sub>50<\/jats:sub>\u2009=\u20090.059\u2009\u00b1\u20090.008\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) or carbachol (EC<jats:sub>50<\/jats:sub>\u2009=\u20090.068\u2009\u00b1\u20090.007\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL). These results suggest the possible decrease of calcium influx underlying the effects of menthofuran on the gastrointestinal tract, which opens the door for further study regarding this potential application for the treatment of gastrointestinal disorders, noting possible limitations of its use due to adverse effects in children.<\/jats:p>","DOI":"10.1155\/2023\/2726794","type":"journal-article","created":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T03:50:07Z","timestamp":1686455407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypokinetic Activity of Menthofuran on the Gastrointestinal Tract in Rodents"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3489-6888","authenticated-orcid":false,"given":"Railson de 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