{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:34:43Z","timestamp":1788669283093,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271134"],"award-info":[{"award-number":["32271134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771456"],"award-info":[{"award-number":["81771456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970979"],"award-info":[{"award-number":["31970979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82090034"],"award-info":[{"award-number":["82090034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GXXT-2021-003"],"award-info":[{"award-number":["GXXT-2021-003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Synergy Innovation Program of Anhui Province","award":["32271134"],"award-info":[{"award-number":["32271134"]}]},{"name":"University Synergy Innovation Program of Anhui Province","award":["81771456"],"award-info":[{"award-number":["81771456"]}]},{"name":"University Synergy Innovation Program of Anhui Province","award":["31970979"],"award-info":[{"award-number":["31970979"]}]},{"name":"University Synergy Innovation Program of Anhui Province","award":["82090034"],"award-info":[{"award-number":["82090034"]}]},{"name":"University Synergy Innovation Program of Anhui Province","award":["GXXT-2021-003"],"award-info":[{"award-number":["GXXT-2021-003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2023,12,7]]},"abstract":"<jats:p>\n                    Background. Obsessive\u2013compulsive disorder (OCD) is frequently treated using a combination of counseling, drugs, and, more recently various transcranial stimulation protocols, but all require several weeks to months for clinically significant improvement, so there is a need for treatments with faster onset. This study investigated whether an accelerated high-dose theta burst stimulation (ahTBS) protocol significantly improves the efficacy of OCD compared to traditional 1-Hz repetitive transcranial magnetic stimulation (rTMS) in the routine clinical setting. Method. Forty-five patients with OCD were randomized into two groups and treated with ahTBS or 1-Hz rTMS for 5 days. Patients were assessed at baseline at the end of treatment using the Yale\u2013Brown Obsessive\u2013Compulsive Scale (Y-BOCS). Results. After 5 days of treatment, there was a significant decrease in Y-BOCS scores in both groups (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ), and the difference between the two groups was not statistically significant (group\u2009\u00d7\u2009time interaction, F\u2009=\u20091.90,\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.18<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). There was also no statistically significant difference in other secondary outcome indicators, including depression, anxiety symptoms, and response rate. However, the ahTBS group had a greater trend in response rate. Neuropsychological testing showed no negative cognitive side effects of either treatment. Conclusion. Accelerated high-dose TBS is as safe and has comparable short-term efficacy to traditional 1-Hz rTMS for the clinical treatment of OCD. Further research is needed to explore optimal ahTBS parameters, validate the utility of this treatment modality, and identify factors predictive of rapid clinical response to guide clinical decision-making. This trial is registered with NCT05221632.\n                  <\/jats:p>","DOI":"10.1155\/2023\/2741287","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T15:05:05Z","timestamp":1701961505000},"page":"1-8","source":"Crossref","is-referenced-by-count":17,"title":["A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive\u2013Compulsive Disorder"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9779-9888","authenticated-orcid":true,"given":"Jin","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3282-0209","authenticated-orcid":true,"given":"Ke","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueling","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Tang","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center & Hangzhou Seventh People\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center & Hangzhou Seventh People\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehua","family":"Ma","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center & Hangzhou Seventh People\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Xue","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center & Hangzhou Seventh People\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China"},{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 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Psychological Sciences, Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center & Hangzhou Seventh People\u2019s Hospital, Zhejiang University, School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China"},{"name":"Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China"},{"name":"Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China"},{"name":"Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, 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