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In this study, full open reading frame of <jats:italic>HMGB1a<\/jats:italic> gene from <jats:italic>Piaractus brachypomus<\/jats:italic> is reported as well as its molecular characterization, including tissue gene expression. At predicted protein level, <jats:italic>HMGB1a<\/jats:italic> showed similarities with its orthologs in teleosts and higher vertebrates. The relative gene expression of <jats:italic>HMGB1a<\/jats:italic> mRNA was measured in several tissues including the brain, where a differential expression appeared in brain regions, i.e., higher expression in the cerebellum and telencephalon. In addition, in an assay of sublethal exposure to chlorpyrifos, upregulation of <jats:italic>HMGB1a<\/jats:italic> was detected in optic chiasm. Furthermore, in a traumatic brain injury model, upregulation of <jats:italic>HMGB1a<\/jats:italic> expression was evident 24\u2009hours after lesion and remained higher up to 14\u2009days. These findings suggest a role for <jats:italic>HMGB1a<\/jats:italic> in brain damage and its candidature as biomarker of brain injury; however, more studies are required to elucidate the functions of <jats:italic>HMGB1a<\/jats:italic> and its regulation in <jats:italic>P. brachypomus<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2023\/2774528","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:05:09Z","timestamp":1686117909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular Characterization of High Mobility Group Box 1a (<i>HMGB1a<\/i>) Gene in Red\u2010Bellied Pacu, <i>Piaractus brachypomus<\/i>"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1812-9673","authenticated-orcid":false,"given":"Nicolas","family":"Carrillo-Godoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6980-892X","authenticated-orcid":false,"given":"Iang Schroniltgen","family":"Rond\u00f3n-Barrag\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035755"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.223834"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2018.04.025"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003840"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.146932"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2016.07.034"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2011.03.025"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8264-y"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1567-133x(02)00093-5"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2007.10.004"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2013.12.015"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8533-4"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/are.14784"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43141-022-00296-6"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2022.104353"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aaf.2022.08.008"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367700780387660"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.47886\/9781934874394"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts199"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-890-0:571"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01156-3"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crbiot.2021.01.001"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac278"},{"key":"e_1_2_10_24_2","volume-title":"Prediction of glycosylation across the human proteome and the correlation to protein function","author":"Gupta R.","year":"2002"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.79"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"e_1_2_10_27_2","volume-title":"PyMOL","author":"DeLano W. 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