{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:07:07Z","timestamp":1767168427576,"version":"build-2238731810"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":142,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015310","name":"Natural Science Foundation of Xinjiang","doi-asserted-by":"publisher","award":["2021D01F64"],"award-info":[{"award-number":["2021D01F64"]}],"id":[{"id":"10.13039\/501100015310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700500"],"award-info":[{"award-number":["81700500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["2017NJMU042"],"award-info":[{"award-number":["2017NJMU042"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Respiratory syncytial virus (RSV) is the main pathogen causing acute bronchiolitis, which is common in infants and young children. A previous study revealed the possible involvement of POU class 2 associating factor 1 (POU2AF1) in RSV\u2010triggered acute bronchiolitis. We attempted to clarify the specific action mechanism of POU2AF1 underlying RSV\u2010triggered inflammation.\n                    <jats:italic>Methods<\/jats:italic>\n                    . RT\u2010qPCR measured POU2AF1 levels in RSV\u2010infected children, mice, and airway epithelial cell lines (HBECs). HE staining showed histopathological features in the lung tissue of RSV\u2010infected mice. ELISA examined the contents of proinflammatory cytokines in RSV\u2010infected mice. Western blotting evaluated the protein abundance of proinflammatory cytokines in RSV\u2010infected HBECs and assessed NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B pathway\u2010associated protein expression in RSV\u2010infected mice and RSV\u2010treated HBECs.\n                    <jats:italic>Results<\/jats:italic>\n                    . POU2AF1 presented depletion in RSV\u2010infected children, mice, and HBECs. RSV\u2010infected triggered lung injury and inflammatory cell infiltration in the mouse lung tissue, while POU2AF1 overexpression rescued these changes. RSV\u2010infected induced inflammatory impairment in HBECs, whereas POU2AF1 reversed this effect. POU2AF1 suppressed the upregulated NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B pathway\u2010associated protein expression in mice and HBECs under RSV infection.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . POU2AF1 exerts a protective impact on RSV\u2010induced acute bronchiolitis in vitro and in vivo through the NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B pathway. Our research may provide a novel direction for better therapy of RSV\u2010triggered acute bronchiolitis.\n                  <\/jats:p>","DOI":"10.1155\/2023\/2815219","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T22:05:07Z","timestamp":1684879507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["[Retracted] POU Class 2 Associating Factor 1 Exerts a Protective Effect on the Respiratory Syncytial Virus\u2010Induced Acute Bronchiolitis by the NF\u2010\u03baB Pathway"],"prefix":"10.1155","volume":"2023","author":[{"given":"Liwen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0178-2310","authenticated-orcid":false,"given":"Yu","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3222-0342","authenticated-orcid":false,"given":"Liang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.3109\/01460862.2013.834397"},{"key":"e_1_2_9_2_2","first-page":"1","article-title":"Acute bronchiolitis: assessment and management in the emergency department","volume":"16","author":"Joseph M. 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