{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:04:23Z","timestamp":1792512263043,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008809","name":"University of Hail","doi-asserted-by":"publisher","award":["RD-21035"],"award-info":[{"award-number":["RD-21035"]}],"id":[{"id":"10.13039\/501100008809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Clinical multi\u2010drug\u2010resistant bacteria continue to be a serious health problem. Plant\u2010derived molecules are an important source of bioactive compounds to counteract these pathogenic bacteria. In this paper, we studied the chemical composition of the methanol (80%) extract from <jats:italic>Pithecellobium dulce<\/jats:italic> seed (Hail, Saudi Arabia) and its ability to inhibit the growth of clinically relevant multi\u2010drug\u2010resistant bacteria. Molecular docking analysis was performed to predict the best compounds with low binding energy and high affinity to interact with two <jats:italic>Staphylococcus aureus<\/jats:italic> receptors. Data showed that <jats:italic>P. dulce<\/jats:italic> extract is a rich source of D\u2010turanose (55.82%), hexadecanoic acid (11.56%), indole\u20101\u2010acetic acid (11.42%), inositol (5.78%), and octadecanoic acid (4.36%). The obtained extract showed antibacterial activity towards tested clinical bacterial strains with MIC values ranging from 233\u2009mg\/mL for <jats:italic>Acinetobacter baumannii<\/jats:italic> to 300\u2009mg\/mL for <jats:italic>S. aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic>. Turanose interaction has resulted in \u20107.4 and \u20106.6\u2009kcal\/mol for 1JIJ and 2XCT macromolecules, while inositol showed energy values (\u22127.2 and \u22125.4\u2009kcal\/mol) for the same receptors. Multiple identified compounds showed desirable bioavailability properties indicating its great potential therapeutic use in human. Overall, current investigation highlights the possible use of <jats:italic>P. dulce<\/jats:italic> extract as a valuable source for drug development against pathogenic drug\u2010resistant bacteria.<\/jats:p>","DOI":"10.1155\/2023\/2848198","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T18:20:07Z","timestamp":1675534807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Antimicrobial Potential of <i>Pithecellobium dulce<\/i> Seed Extract against Pathogenic Bacteria: In Silico and In Vitro Evaluation"],"prefix":"10.1155","volume":"2023","author":[{"given":"Abdu","family":"Aldarhami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-0278","authenticated-orcid":false,"given":"Abdulrahman S.","family":"Bazaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah S.","family":"Alhamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel F.","family":"Alghaith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Rizwan","family":"Ahamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasseen A.","family":"Alassmrry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3371-0477","authenticated-orcid":false,"given":"Talal","family":"Alharazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mejdi","family":"Snoussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3068-0313","authenticated-orcid":false,"given":"Husam","family":"Qanash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulwahab","family":"Alamri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-7744","authenticated-orcid":false,"given":"Riadh","family":"Badraoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Kadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-6361","authenticated-orcid":false,"given":"Naif K.","family":"Binsaleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousa","family":"Alreshidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,4]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4065603"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10030495"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2019.12.001"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10101907"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.18882"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/2231-4040.104709"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/app12199928"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27154824"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09993-1"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/heapol\/czw022"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13329"},{"key":"e_1_2_9_13_2","first-page":"70","article-title":"Phytochemical Analysis and Antimicrobial Efficacy of Leaf Extracts of Pithecellobium dulce","volume":"6","author":"Kumar M.","year":"2013","journal-title":"Asian Journal of Pharmaceutical and Clinical Research"},{"key":"e_1_2_9_14_2","first-page":"700","article-title":"Medicinal uses of Pithecellobium dulce and its health benefits","volume":"7","author":"Kulkarni K. 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