{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:18:41Z","timestamp":1791908321711,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021A04704"],"award-info":[{"award-number":["CI2021A04704"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . This nationwide, multicenter prospective observational study with a patient registry was designed to evaluate the efficacy of Fufang E\u2019jiao Jiang (FEJ) in Chinese patients with Qi and blood deficiency syndrome (QBDS).\n                    <jats:italic>Methods<\/jats:italic>\n                    . QBDS patients were consecutively recruited from 81 investigational sites in China from July, 2019, to December, 2020. Patients who met the eligibility criteria were enrolled in a prospective registry database. Baseline characteristics and changes in scores on the traditional Chinese medicine (TCM) symptom evaluation scale for Qi and blood deficiency, the clinical global impression (CGI) scale, the fatigue scale\u201014 (FS\u201014), and the Pittsburgh sleep quality index (PSQI) were analyzed to determine the clinical efficacy of FEJ.\n                    <jats:italic>Results<\/jats:italic>\n                    . A total of 3,203 patients were recruited. The average remission rate (i.e., the sum of the cure rate and improvement rate) of the 20 symptoms of QBDS was 92.49% after 4\u2009weeks of FEJ treatment, which was higher than at baseline; the rate increased to 94.69% at 8\u2009weeks. The CGI scale revealed that the number of total remissions at 4 and 8\u2009weeks was 3,120 (97.41%) and 415 (100%), respectively. The total FS\u201014 scores decreased by 1.67\u2009\u00b1\u20094.11 (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) at 4\u2009weeks and 1.72\u2009\u00b1\u20093.09 (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) at 8\u2009weeks of treatment. The PSQI scores were 6.6\u2009\u00b1\u20094.7 and 6.52\u2009\u00b1\u20093.07 at 4 and 8\u2009weeks, respectively, which were significantly lower than the baseline scores (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0033). Both the subhealth fatigue (SF) and iron deficiency anemia (IDA) groups showed significantly improved clinical symptoms of QBDS (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01). Between\u2010group comparisons revealed significantly greater improvements in FS\u201014 and PSQI scores in the SF group than in the IDA group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). A multivariate logistic regression analysis showed that disease course, FS\u201014 score at baseline, and four\u2010week FEJ doses were independent risk factors for the degree of symptom relief in QBDS patients (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . In real\u2010world settings, FEJ has a promising effect in treating QBDS and can significantly improve the severity of its symptoms.\n                  <\/jats:p>","DOI":"10.1155\/2023\/3179489","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T21:50:06Z","timestamp":1675461006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of Fufang E\u2019jiao Jiang in the Treatment of Patients with Qi and Blood Deficiency Syndrome: A Real\u2010World Prospective Multicenter Study with a Patient Registry"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-5226","authenticated-orcid":false,"given":"Mengjie","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengli","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0327-0594","authenticated-orcid":false,"given":"Jiake","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panbo","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanfei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guida","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-2368","authenticated-orcid":false,"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-7801","authenticated-orcid":false,"given":"Fang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"134","article-title":"Analysis on regularity of prescriptions in treatment of Qi and blood deficiency syndrome based on listed Chinese patent medicines","volume":"47","author":"Guan S.","year":"2020","journal-title":"Liaoning Journal of Traditional Chinese Medicine"},{"key":"e_1_2_10_2_2","volume-title":"Clinic Terminology of Traditional Chinese Medical Diagnosis and Treatment-Part 2:Syndromes\/patterns","author":"The State Bureau of Quality and Technical Supervision","year":"1997"},{"key":"e_1_2_10_3_2","first-page":"122","article-title":"Analysis of TCM physical characteristics of people with fatigue subhealth status","volume":"25","author":"Yang J.","year":"2018","journal-title":"Chinese Journal of Traditional Medical Science and Technology"},{"key":"e_1_2_10_4_2","first-page":"1","article-title":"Analysis on the sub-health intervention under the direction of TCM theory","volume":"11","author":"Zhang J.","year":"2013","journal-title":"Chinese Medicine Modern Distance Education of China"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9950890"},{"key":"e_1_2_10_6_2","first-page":"54","article-title":"Intervention of buzhong Yiqi decoction combined with ginger partitioned moxibustion on sub-health population with Qi deficiency","volume":"35","author":"Li Z.","year":"2020","journal-title":"Journal of Hebei Traditional Chinese Medicine and Pharmacology"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon.15.75"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2007.25.18_suppl.2552"},{"key":"e_1_2_10_9_2","first-page":"148","article-title":"Adverse reaction to intravenous iron: hypersensitivity or secondary side effect?","volume":"33","author":"Sirvent-Pedre\u00f1o A. 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