{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:24:28Z","timestamp":1791944668013,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2023,6,16]]},"abstract":"<jats:p>Background. Reversible P2Y12 inhibition can be obtained with cangrelor administered intravenously. More experience with cangrelor use in acute PCI with unknown bleeding risk is needed. Objectives. To describe real-world use of cangrelor including patient and procedure characteristics and patient outcomes. Methods. We performed a single-centre, retrospective, and observational study including all patients treated with cangrelor in relation to percutaneous coronary intervention at Aarhus University Hospital during the years 2016, 2017, and 2018. We recorded procedure indication and priority, the indications for cangrelor use, and patient outcomes within the first 48\u2009hours after initiation of cangrelor treatment. Results. We treated 991 patients with cangrelor in the study period. Of these, 869 (87.7%) had an acute procedure priority. Among acute procedures, patients were mainly treated for STEMI (n\u2009=\u2009723) and the remaining were treated for cardiac arrest and acute heart failure. Use of oral P2Y12 inhibitors prior to percutaneous coronary intervention was rare. Fatal bleeding events (n\u2009=\u20096) were only observed among patients undergoing acute procedures. Stent thrombosis was observed in two patients receiving acute treatment for STEMI. Thus, cangrelor can be used in relation to PCI under acute circumstances with advantages in terms of clinical management. The benefits and risks, in terms of patient outcomes, should ideally be assessed in randomized trials.<\/jats:p>","DOI":"10.1155\/2023\/3197512","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T02:50:05Z","timestamp":1686970205000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Real-World Experience with Cangrelor as Adjuvant to Percutaneous Coronary Intervention: A Single-Centre Observational Study"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-5559","authenticated-orcid":true,"given":"Troels","family":"Thim","sequence":"first","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-9253","authenticated-orcid":true,"given":"Lars","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekka Vibjerg","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaj","family":"St\u00f8ttrup","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Eftekhari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1466-0865","authenticated-orcid":true,"given":"Erik Lerkevang","family":"Grove","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne B\u00f8jet","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Thorsted","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Carstensen","sequence":"additional","affiliation":[{"name":"Emergency Department, Bispebjerg University Hospital, Bispebjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Amiri","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten Tange","family":"Veien","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evald H\u00f8j","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Juhl","family":"Terkelsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009344986"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0908628"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0908629"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1300815"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvz002"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.2002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2147\/clep.s10190"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.009449"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy462"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy223"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-21-00181"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"}],"container-title":["Cardiology 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