{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:25:20Z","timestamp":1793139920055,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["FA4Lin"],"award-info":[{"award-number":["FA4Lin"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["200110"],"award-info":[{"award-number":["200110"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education and Science of the Republic of Serbia","award":["FA4Lin"],"award-info":[{"award-number":["FA4Lin"]}]},{"name":"Ministry of Education and Science of the Republic of Serbia","award":["200110"],"award-info":[{"award-number":["200110"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2023,4,6]]},"abstract":"<jats:p>Pathogenesis of chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) remains unclear since it represents an interplay between immunological, endocrine, and neuropsychiatric factors. Patients suffering from CP\/CPPS often develop mental health-related disorders such as anxiety, depression, or cognitive impairment. The aim of this study was to investigate depression-like behavior, learning, and memory processes in a rat model of CP\/CPPS and to determine the alterations in hippocampal structure and function. Adult male Wistar albino rats (<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>n<\/a:mi><a:mo>=<\/a:mo><a:mn>6<\/a:mn><\/a:math><\/jats:inline-formula>in each group) from CP\/CPPS (single intraprostatic injection of 3% \u03bb-carrageenan, day 0) and Sham (0.9% NaCl) groups were subjected to pain threshold test (days 2, 3, and 7), depression-like behavior, and learning-memory tests (both on day 7). Decreased pain threshold in the scrotal region and histopathological presence of necrosis and inflammatory infiltrate in prostatic tissue confirmed the development of CP\/CPPS. The forced swimming test revealed the depression-like behavior evident through increased floating time, while the modified elevated plus maze test revealed learning and memory impairment through prolonged transfer latency in the CP\/CPPS group in comparison with Sham (<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>p<\/c:mi><c:mo>&lt;<\/c:mo><c:mn>0.001<\/c:mn><\/c:math><\/jats:inline-formula>and<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>p<\/e:mi><e:mo>&lt;<\/e:mo><e:mn>0.001<\/e:mn><\/e:math><\/jats:inline-formula>, respectively). Biochemical analysis showed decreased serum levels of testosterone in CP\/CPPS group vs. the Sham (<jats:inline-formula><g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><g:mi>p<\/g:mi><g:mo>&lt;<\/g:mo><g:mn>0.001<\/g:mn><\/g:math><\/jats:inline-formula>). The CP\/CPPS induced a significant upregulation of ICAM-1 in rat cortex (<jats:inline-formula><i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><i:mi>p<\/i:mi><i:mo>&lt;<\/i:mo><i:mn>0.05<\/i:mn><\/i:math><\/jats:inline-formula>) and thalamus (<jats:inline-formula><k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><k:mi>p<\/k:mi><k:mo>&lt;<\/k:mo><k:mn>0.01<\/k:mn><\/k:math><\/jats:inline-formula>) and increased GFAP expression in the hippocampal astrocytes (<jats:inline-formula><m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><m:mi>p<\/m:mi><m:mo>&lt;<\/m:mo><m:mn>0.01<\/m:mn><\/m:math><\/jats:inline-formula>) vs. Sham, suggesting subsequent neuroinflammation and astrocytosis. Moreover, a significantly decreased number of DCX+ and Ki67+ neurons in the hippocampus was observed in the CP\/CPPS group (<jats:inline-formula><o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><o:mi>p<\/o:mi><o:mo>&lt;<\/o:mo><o:mn>0.05<\/o:mn><\/o:math><\/jats:inline-formula>) vs. Sham, indicating decreased neurogenesis and neuronal proliferation. Taken together, our data indicates that CP\/CPPS induces depression-like behavior and cognitive declines that are at least partly mediated by neuroinflammation and decreased neurogenesis accompanied by astrocyte activation.<\/jats:p>","DOI":"10.1155\/2023\/3199988","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T14:20:15Z","timestamp":1680790815000},"page":"1-14","source":"Crossref","is-referenced-by-count":13,"title":["Chronic Prostatitis\/Chronic Pelvic Pain Syndrome Induces Depression-Like Behavior and Learning-Memory Impairment: A Possible Link with Decreased Hippocampal Neurogenesis and Astrocyte Activation"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-3247","authenticated-orcid":true,"given":"Nikola","family":"\u0160utulovi\u0107","sequence":"first","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-5466","authenticated-orcid":true,"given":"Milena","family":"Veskovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathophysiology \u201cLjubodrag Buba Mihailovic\u201d, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5921-974X","authenticated-orcid":true,"given":"Nela","family":"Pu\u0161ka\u0161","sequence":"additional","affiliation":[{"name":"Institute of Histology and Embryology \u201cAleksandar \u0110. 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