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During her hospitalisation, she never developed cardiocirculatory failure but presented acute kidney injury (AKI) with oliguria. Laboratory investigations confirmed AKI with serum creatinine 2.55\u2009mg\/dL which peaked at 6.49\u2009mg\/dL. There was also evidence for disseminated intravascular coagulation (DIC) with decreased platelet count, low fibrinogen levels, and high D-dimer levels. There were no signs of haemolytic anaemia. The initial ADAMTS13 activity was low (17%) but slowly recovered. Renal function progressively improved with supportive therapy, as opposed to the progressing skin necrosis. The association of DIC and low ADAMTS13 activity may have contributed to the severity of microthrombotic complications, even in the absence of thrombotic microangiopathy as thrombotic thrombocytopenic purpura (TTP) or pneumococcal-associated haemolytic uremic syndrome (pa-HUS).<\/jats:p>","DOI":"10.1155\/2023\/3283606","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T19:05:08Z","timestamp":1682795108000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Streptococcus Pneumoniae Bacteremia with Acute Kidney Injury and Transient ADAMTS13 Deficiency"],"prefix":"10.1155","volume":"2023","author":[{"given":"Sam","family":"Van Hove","sequence":"first","affiliation":[{"name":"Department of Intensive Care, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Werion","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Universit\u00e9 Catholique de Louvain, Neuve, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahalieyah","family":"Anantharajah","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Belkhir","sequence":"additional","affiliation":[{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Universit\u00e9 Catholique de Louvain, Neuve, Belgium"},{"name":"Department of Internal Medicine and Infectious Diseases, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Astrid","family":"van Dievoet","sequence":"additional","affiliation":[{"name":"Laboratory of Hemostasis, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-3352","authenticated-orcid":true,"given":"Philippe","family":"Hantson","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium"},{"name":"Louvain Centre for Toxicology and Applied Pharmacology, Universit\u00e9 Catholique de Louvain, 1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.10.005"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(22)01202-8"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-019-04342-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1515\/med-2020-0030"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7916"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1277300"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-189707000-00002"},{"issue":"2","key":"8","first-page":"154","article-title":"Glomerular and arteriolar thrombosis in pneumococcal septicaemia","volume":"89","author":"E. 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