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To address this challenge, there is a need to generate baseline data on the prevalence and AMR profile of the main disease\u2010causing bacteria. Here, we interrogated the prevalence of bacteria in the nasal cavity of healthy pastoralists in Kajiado Central Subcounty, Kenya, and the occurrence of AMR in Staphylococcus isolates among the study subjects. Nasal swabs from 176 pastoralists were cultured, and the bacteria isolates identified using standard phenotypic and biochemical bacteriological methods. Among the obtained 195 isolates, the most prevalent isolates were coagulase\u2010negative Staphylococcus (CoNS) (44.9%), followed by <jats:italic>Enterococci<\/jats:italic> spp. (43.2%) while <jats:italic>Staphylococcus aureus<\/jats:italic> prevalence was 8%. Antimicrobial sensitivity of the <jats:italic>Staphylococcus<\/jats:italic> spp. isolates to 14 antibiotics representing six antibiotic groups was undertaken using the Kirby\u2010Bauer disk diffusion method. Among the CoNS, the highest resistance was reported in amoxicillin (78.7%) and ceftazidime (76%), while the most resistance for <jats:italic>S. aureus<\/jats:italic> was reported in ceftazidime (100%), amoxicillin (71.4%), and streptomycin (71.4%). From an administered questionnaire looking at gender, animal contact frequency, history of hospital visitation and antibiotic usage, and habitual intake of raw milk, the study showed that male participants had a higher risk of carrying multiple drug resistant (MDR) bacteria than females (<jats:italic>p<\/jats:italic> = 0.02, OR = 1.3). Likewise, habitual intake of raw milk was significantly associated MDR acquisition (<jats:italic>p<\/jats:italic> = 0.02, OR = 1.82). This study reveals a high prevalence of AMR Staphylococcus isolates in the study area laying a foundation for further analysis of molecular characterization of the observed resistance as well as the development of interventions that can reduce the occurrence of AMR in the study area.<\/jats:p>","DOI":"10.1155\/2023\/3573056","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T20:35:07Z","timestamp":1681245307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevalence and Potential Risk Factors for the Acquisition of Antibiotic\u2010Resistant <i>Staphylococcus<\/i> spp. Bacteria Among Pastoralist Farmers in Kajiado Central Subcounty, 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