{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:52:03Z","timestamp":1747191123280,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2023,7,8]]},"abstract":"<jats:p>We describe the case of a 13-year-old girl who presented with a new-onset seizure and fever and subsequently developed severe cardiac dysfunction, coronary artery dilation, and shock due to the surprising diagnosis of multisystem inflammatory syndrome in children (MIS-C). Although the clinical entity we now call MIS-C was first mentioned in the medical literature in April 2020, the full picture of this disease process is still evolving. Neurologic involvement has been described in cases with MIS-C; however, seizures are not a typical presenting symptom. Additionally, because children infected with SARS-CoV-2 are often asymptomatic, a documented preceding COVID-19 infection might not be available to raise suspicion of MIS-C early on. Febrile seizures, meningitis, and encephalitis are childhood illnesses that pediatricians are generally familiar with, but associating these clinical pictures with MIS-C is uncommon. Given the possibility of rapid clinical cardiogenic decline, as seen in our patient, a prompt diagnosis and appropriate monitoring and treatment are of utmost importance. This case report aims to raise awareness that new-onset seizures with fevers can be early or the first presenting symptoms in children with MIS-C, and further workup and close monitoring may be required.<\/jats:p>","DOI":"10.1155\/2023\/3581310","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T20:50:07Z","timestamp":1688849407000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Seizure as Presenting Symptom of Multisystem Inflammatory Syndrome in Children"],"prefix":"10.1155","volume":"2023","author":[{"given":"Eleonora S.","family":"D\u2019Ambrosio","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Massachusetts Medical Center, University of Massachusetts Chan Medical School, 55 Lake Avenue North, Worcester, MA 01655, 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2021680"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)31094-1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.0630"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2021756"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.33314\/jnhrc.v19i1.3410"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2021.01.007"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135567"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2020.e00942"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.07.062"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)31725-6"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0694"}],"container-title":["Case Reports in 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