{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T22:08:58Z","timestamp":1774908538395,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2023,2,27]]},"abstract":"<jats:p>As a highly malignant tumor, the morbidity and mortality of cutaneous melanoma (CM) are increasing year by year. A novel type of cell death connected to mitochondrial metabolism is called cuproptosis. Cuproptosis regulates tumor biological behavior. Thus, genes controlling cuproptosis could be a promising candidate bioindicator for cancer therapy. Datasets of CM patients were obtained from the public database that includes clinical information and RNA-seq data. We divided CM patients into three different subgroups by unsupervised clustering method and explored the differences in functional pathways among the three subgroups by GSVA to prove the possible potential mechanism of copper death-related genes in the formation and development of CM. Secondly, we used differential analysis and Cox regression analysis to find the differential genes related to prognosis, constructed the CRG score, found the critical score for dividing high and low CRG score groups, and then analyzed the prognosis and immune infiltration of high and low CRG score groups. The results show a great correlation between OS and CRG scores. Compared with patients with high CRG scores, patients with low CRG scores have a significantly higher survival rate. In a word, copper sagging plays a certain role in the progress of CM.<\/jats:p>","DOI":"10.1155\/2023\/3615688","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:50:08Z","timestamp":1677545408000},"page":"1-15","source":"Crossref","is-referenced-by-count":8,"title":["Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous Melanoma"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2210-8701","authenticated-orcid":true,"given":"Wentao","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6165-7952","authenticated-orcid":true,"given":"Fu","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiji","family":"Jike","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7898-2927","authenticated-orcid":true,"given":"Ang","family":"Li","sequence":"additional","affiliation":[{"name":"Emergency Center, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126395"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2020.00318"},{"issue":"8","key":"3","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G","article-title":"The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade","volume":"83","author":"A. 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