{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T06:15:11Z","timestamp":1770531311341,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2023,4,15]]},"abstract":"<jats:p>Background. Pulmonary sarcoidosis predominantly affects the upper lung zones but sometimes affects the lower lung zones. We hypothesised that patients with lower lung zone-dominant sarcoidosis had lower baseline forced vital capacity, progressive restrictive lung function decline, and higher long-term mortality. Methods. We retrospectively reviewed clinical data including the pulmonary function tests of 108 consecutive patients with pulmonary sarcoidosis pathologically confirmed by lung and\/or mediastinal lymph node biopsy from 2004 to 2014 from our database. Results. Eleven patients (10.2%) with lower lung zone-dominant sarcoidosis were compared with 97 patients with nonlower lung zone-dominant sarcoidosis. The median age of the patients with lower dominance was significantly older (71 vs. 56, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.0005<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The patient with lower dominance had a significantly lower baseline percent forced vital capacity (FVC) (96.0% vs. 103%, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.022<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The annual change in FVC was \u2212112\u2009mL in those with lower dominance vs. 0\u2009mL in nonlower dominance (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.0033<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Fatal acute deterioration was observed in three patients (27%) in the lower dominant group. Overall survival in the lower dominant group was significantly worse. Conclusions. Patients with lower lung zone-dominant sarcoidosis had an older age and lower baseline FVC with disease progression and acute deterioration associated with higher long-term mortality.<\/jats:p>","DOI":"10.1155\/2023\/3624344","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T17:05:10Z","timestamp":1681578310000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Poor Outcome and Mortality in Patients with Lower Lung-Dominant Sarcoidosis"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3180-1638","authenticated-orcid":true,"given":"Kazunobu","family":"Tachibana","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan"},{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-8105","authenticated-orcid":true,"given":"Masanori","family":"Akira","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan"},{"name":"Department of Radiology, Katano Hospital, Katano City, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2222-0683","authenticated-orcid":true,"given":"Toru","family":"Arai","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0237-0080","authenticated-orcid":true,"given":"Chikatoshi","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan"},{"name":"Sugimoto Naika Clinic, Sakai City, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7893-5546","authenticated-orcid":true,"given":"Seiji","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Aihara Daini Hospital, Osaka City, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-874X","authenticated-orcid":true,"given":"Yoshikazu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198108203050804"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.172.2.2748828"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.1385"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1984.130.1.29"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.93.06030349"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7394"},{"issue":"2","key":"7","first-page":"736","article-title":"Statement on sarcoidosis. 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