{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:15:20Z","timestamp":1777108520488,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","award":["QDFYQN202102040"],"award-info":[{"award-number":["QDFYQN202102040"]}],"id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Donor lung ventilation and inflation during the warm ischemia could attenuate ischemia\u2010reperfusion injury (IRI) after lung transplantation. Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S), as a kind of protective gas, has demonstrated the antilung IRI effect. This study is aimed at observing the different methods of administering H<jats:sub>2<\/jats:sub>S in the setting of warm ischemia, ventilation, and inflation on the lung graft from a rat non\u2010heart\u2010beating donor. After 1\u2009h of cardiac arrest, donor lungs in situ were inflated with 80\u2009ppm H<jats:sub>2<\/jats:sub>S (FS group), ventilated with 80\u2009ppm H<jats:sub>2<\/jats:sub>S (VS group), or deflated (control group) for 2\u2009h. Then, the lung transplantation was performed after 3\u2009h cold ischemia. The rats without ischemia and reperfusion were in the sham group. Pulmonary surfactant in the bronchoalveolar lavage fluid was measured in donor lung. The inflammatory response, cell apoptosis, and lung graft function were assessed at 3\u2009h after reperfusion. The lung injury was exacerbated in the control group, which was attenuated significantly after the H<jats:sub>2<\/jats:sub>S treatment. Compared with the FS group, the pulmonary surfactant in the donor was deteriorated, the lung oxygenation function was decreased, and the inflammatory response and cell apoptosis were increased in the graft in the VS group (<jats:italic>P<\/jats:italic> &lt; 0.05). In conclusion, H<jats:sub>2<\/jats:sub>S inflation during the warm ischemia phase improved the function of lung graft via regulating pulmonary surfactant stability and decreased the lung graft IRI via decreasing the inflammatory response and cell apoptosis.<\/jats:p>","DOI":"10.1155\/2023\/3645304","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T18:35:59Z","timestamp":1675362959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Inflation and Ventilation with Hydrogen Sulfide during the Warm Ischemia Phase on Ischemia\u2010Reperfusion Injury in a Rat Model of Non\u2010Heart\u2010Beating Donor Lung Transplantation"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-5374","authenticated-orcid":false,"given":"Junwei","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4887-8595","authenticated-orcid":false,"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9501-6440","authenticated-orcid":false,"given":"Junmin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1940-2611","authenticated-orcid":false,"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3528-9938","authenticated-orcid":false,"given":"Han","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6436-3300","authenticated-orcid":false,"given":"Guangqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-7381","authenticated-orcid":false,"given":"Yanwei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-1307","authenticated-orcid":false,"given":"Chao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.07.009"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.07.092"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12167"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902952106"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0684-4"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33101-x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20080021"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2015.1052549"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.10.031"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014597"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17304880"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000189554.41095.98"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2005.00153.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001215)89:12<2637::AID-CNCR17>3.0.CO;2-B"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01266-1"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200007000-00059"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.5.1943"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181de7107"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.09.028"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.9910064"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301858200"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366-6999.20120809"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2012007500090"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01514.x"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.68.072304.113443"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2011.05.028"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2333-y"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.099762"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318182aef1"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2023\/3645304.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2023\/3645304.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2023\/3645304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T23:31:46Z","timestamp":1722900706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2023\/3645304"}},"subtitle":[],"editor":[{"given":"Xing","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1155\/2023\/3645304"],"URL":"https:\/\/doi.org\/10.1155\/2023\/3645304","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3645304"}}