{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:58:48Z","timestamp":1767833928143,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"A\u2217STAR Industry Alignment Fund","award":["H19\/01\/a01\/023"],"award-info":[{"award-number":["H19\/01\/a01\/023"]}]},{"name":"A\u2217STAR Industry Alignment Fund","award":["NMRC\/CG\/M011\/2017 SGH"],"award-info":[{"award-number":["NMRC\/CG\/M011\/2017 SGH"]}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["H19\/01\/a01\/023"],"award-info":[{"award-number":["H19\/01\/a01\/023"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CG\/M011\/2017 SGH"],"award-info":[{"award-number":["NMRC\/CG\/M011\/2017 SGH"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Biomedical Imaging"],"published-print":{"date-parts":[[2023,7,19]]},"abstract":"<jats:p>Background. Bariatric surgery is the most effective treatment for morbid obesity and reduces the severity of nonalcoholic fatty liver disease (NAFLD) in the long term. Less is known about the effects of bariatric surgery on liver fat, inflammation, and fibrosis during the early stages following bariatric surgery. Aims. This exploratory study utilises advanced imaging methods to investigate NAFLD and fibrosis changes during the early metabolic transitional period following bariatric surgery. Methods. Nine participants with morbid obesity underwent sleeve gastrectomy. Multiparametric MRI (mpMRI) and magnetic resonance elastography (MRE) were performed at baseline, during the immediate (1 month), and late (6 months) postsurgery period. Liver fat was measured using proton density fat fraction (PDFF), disease activity using iron-correct T1 (cT1), and liver stiffness using MRE. Repeated measured ANOVA was used to assess longitudinal changes and Dunnett\u2019s method for multiple comparisons. Results. All participants (Age <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mn>45.1<\/a:mn>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mn>9.0<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> years, BMI <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mn>39.7<\/c:mn>\n                        <c:mo>\u00b1<\/c:mo>\n                        <c:mn>5.3<\/c:mn>\n                        <c:mtext>\u2009<\/c:mtext>\n                        <c:mtext>kg<\/c:mtext>\n                        <c:mo>\/<\/c:mo>\n                        <c:msup>\n                           <c:mrow>\n                              <c:mtext>m<\/c:mtext>\n                           <\/c:mrow>\n                           <c:mrow>\n                              <c:mn>2<\/c:mn>\n                           <\/c:mrow>\n                        <\/c:msup>\n                     <\/c:math>\n                  <\/jats:inline-formula>) had elevated hepatic steatosis at baseline (PDFF &gt;5%). In the immediate postsurgery period, PDFF decreased significantly from <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mn>14.1<\/e:mn>\n                        <e:mo>\u00b1<\/e:mo>\n                        <e:mn>7.4<\/e:mn>\n                        <e:mi>%<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula> to 8<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mn>.9<\/g:mn>\n                        <g:mo>\u00b1<\/g:mo>\n                        <g:mn>4.4<\/g:mn>\n                        <g:mi>%<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula> (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.016<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>) and cT1 from <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mn>826.9<\/k:mn>\n                        <k:mo>\u00b1<\/k:mo>\n                        <k:mn>80.6<\/k:mn>\n                        <k:mtext>\u2009<\/k:mtext>\n                        <k:mtext>ms<\/k:mtext>\n                     <\/k:math>\n                  <\/jats:inline-formula> to <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mn>768.4<\/m:mn>\n                        <m:mo>\u00b1<\/m:mo>\n                        <m:mn>50.9<\/m:mn>\n                        <m:mtext>\u2009<\/m:mtext>\n                        <m:mtext>ms<\/m:mtext>\n                     <\/m:math>\n                  <\/jats:inline-formula> (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>p<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.047<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>). These improvements continued to the later postsurgery period. Bariatric surgery did not reduce liver stiffness measurements. Conclusion. Our findings support using MRI as a noninvasive tool to monitor NAFLD in patient with morbid obesity during the early stages following bariatric surgery.<\/jats:p>","DOI":"10.1155\/2023\/4228321","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T23:20:09Z","timestamp":1689808809000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to Evaluate the Early Effects of Bariatric Surgery on Nonalcoholic Fatty Liver Disease"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-7158","authenticated-orcid":true,"given":"Hong Chang","family":"Tan","sequence":"first","affiliation":[{"name":"Singapore General Hospital, Singapore"}]},{"given":"Elizabeth","family":"Shumbayawonda","sequence":"additional","affiliation":[{"name":"Perspectum Ltd., UK"}]},{"given":"Cayden","family":"Beyer","sequence":"additional","affiliation":[{"name":"Perspectum Ltd., UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-7868","authenticated-orcid":true,"given":"Lionel Tim-Ee","family":"Cheng","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}]},{"given":"Albert","family":"Low","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}]},{"given":"Chin Hong","family":"Lim","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}]},{"given":"Alvin","family":"Eng","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}]},{"given":"Weng Hoong","family":"Chan","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}]},{"given":"Phong Ching","family":"Lee","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}]},{"given":"Mei Fang","family":"Tay","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}]},{"given":"Stella","family":"Kin","sequence":"additional","affiliation":[{"name":"Perspectum Ltd., UK"}]},{"given":"Jason Pik Eu","family":"Chang","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}]},{"given":"Yong Mong","family":"Bee","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}]},{"given":"George Boon Bee","family":"Goh","sequence":"additional","affiliation":[{"name":"Singapore General Hospital, Singapore"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199911001-00019"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-00570-y"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-12009-8"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.052"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.006"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.033"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.1532"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082649"},{"key":"9","volume-title":"Obesity: Clinical Assessment and Management","author":"National Institute for Health and Care Excellence","year":"2016"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-018-3286-9"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1687"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2925-x"},{"issue":"8","key":"13","first-page":"S1","article-title":"Noninvasive tests (NITs) in the management of nonalcoholic steatohepatitis (NASH)","volume":"16","author":"S. 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