{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:13:57Z","timestamp":1787588037490,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":298,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022050","name":"Adigrat University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009402","name":"Mekelle University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    The stomach and upper part of the small intestine are where furosemide is primarily absorbed when treating edema brought on by congestive heart failure (CHF), hepatic cirrhosis, renal impairment, and nephrotic syndrome. This narrow absorption window is responsible for furosemide\u2019s limited oral bioavailability. So creating a gastroretentive floating tablet could be beneficial. Natural polymers are advised for use in medication delivery because they are readily available in nature, biodegradable, relatively inexpensive, biocompatible, and nontoxic. Olibanum is a natural plant\u2010based polymer obtained from Boswellia genus of trees and mainly composed of alcohol\u2010soluble resin (65\u201085%). Ethiopia is rich in Boswellia species, with Boswellia papyrifera being the most important oleo\u2010gum resin\u2010producing tree species. In order to formulate a gastroretentive floating matrix tablet of furosemide, this study looked at the use of naturally occurring, locally available B. papyrifera resin as a matrix\u2010forming polymer. By directly compressing B. papyrifera resin and HPMC K4M as matrix\u2010forming polymers and sodium bicarbonate as a gas\u2010generating agent, floating matrix tablets were created. The effects of the formulation variables polymer type, polymer concentration, polymer ratio, and percentage of the floating agent on the floating lag time, total floating time (duration), and cumulative drug release in 12 hours were investigated. Furosemide floating tablets formulated employing higher (40%) polymer concentrations (olibanum resin, HPMC K4M, or in combination) and 10% sodium bicarbonate as gas\u2010generating agent demonstrated a floating lag time of less than 6 minutes and a sustained release with a total floating time of more than 12 hours. Comparing the release characteristics of floating tablets made with 40% of a total polymer and 10% of NaHCO3 revealed that the medicine is released very slowly when polymers were combined. The matrix\u2010forming polymer, olibanum resin, obtained from\n                    <jats:italic>B. papyrifera<\/jats:italic>\n                    , was effectively used to make furosemide floating matrix tablets. The olibanum resin from\n                    <jats:italic>B. papyrifera<\/jats:italic>\n                    can therefore be used as a potential substitute matrix\u2010forming polymer in the production of effervescent floating matrix tablets.\n                  <\/jats:p>","DOI":"10.1155\/2023\/4322375","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T12:20:36Z","timestamp":1698322836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Formulation and\n                    <i>In Vitro<\/i>\n                    Evaluation of Furosemide Floating Matrix Tablets Using\n                    <i>Boswellia papyrifera<\/i>\n                    Resin as Matrix Forming Polymer"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-8369","authenticated-orcid":false,"given":"Adane","family":"Yehualaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7792-5704","authenticated-orcid":false,"given":"Chernet","family":"Tafere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6350-4933","authenticated-orcid":false,"given":"Zewdu","family":"Yilma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Abrha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"32","article-title":"Sustained release effervescent floating bilayer tablets - a review of novel approach","volume":"5","author":"Dhaneshwar P.","year":"2017","journal-title":"PharmaTutor"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2011.12.011"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-82502012000100003"},{"key":"e_1_2_9_4_2","first-page":"1877","article-title":"Formulation and optimization of sustained release floating matrix tablets of salbutamol sulphate using xanthan gum and hydroxypropyl methylcellulose polymer blend","volume":"6","author":"Yilma Z.","year":"2015","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-8453.83431"},{"key":"e_1_2_9_6_2","first-page":"428","article-title":"A comprehensive review on floating drug delivery system","volume":"2","author":"Sharma N.","year":"2011","journal-title":"International Journal of Pharmaceutical And BioMedical Science"},{"key":"e_1_2_9_7_2","unstructured":"NafeiA. T. Formulation of furosemide as a gastroretentive floating in-situ gelling system for an oral controlled release dosage form Anas Tarik Nafei 2014 MSC. Thesis."},{"key":"e_1_2_9_8_2","volume-title":"Development and evaluation of furosemide buoyant tablet dosage form","author":"Mohamed K. A.","year":"2003"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22030"},{"key":"e_1_2_9_10_2","first-page":"77","article-title":"Review: in-vitro drug release characterization models","author":"Singhvi G.","year":"2011","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_9_11_2","first-page":"611","article-title":"Polymers used in floating drug delivery system: a review","volume":"4","author":"Kulkarni D. 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