{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:00:03Z","timestamp":1784030403540,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":204,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Foundation of Beijing Shijitan Hospital","award":["2017-q43"],"award-info":[{"award-number":["2017-q43"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Since a urinary tract infection (UTI) is easy to relapse and difficult to treat, the antibiotic resistance rate has increased year by year in recent years. This study was to analyze the characteristics of the common pathogenic bacteria and the changes of antibiotic resistance in urinary system infection, so as to guide the standard use of antibiotics in a clinical urinary tract infection and control nosocomial infection effectively. <jats:italic>Methods<\/jats:italic>. A total of 5,669 strains of a urinary tract infection in the hospital from January 2009 to December 2017 were retrospectively analyzed. Bacterial identification and the antibiotic sensitivity test (AST) were analyzed by using a VITEK\u20102 Compact system. <jats:italic>Results<\/jats:italic>. Of the 5669 pathogens, 3,256 (57.44%) of the strains were Gram\u2010negative bacteria (GNB), 1,474 (26%) were Gram\u2010positive bacteria (GPB), and 939 (16.56%) were fungi. Resistant rates of ESBL\u2010producing strains were all significantly different from non\u2010ESBL\u2010producing strains in <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>p<\/jats:italic> &lt; 0.05). The resistance rate of ESBL\u2010producing strains to <jats:italic>\u03b2<\/jats:italic>\u2010lactam antibiotics was all higher than that of non\u2010ESBL\u2010producing strains in <jats:italic>Klebsiella pneumoniae<\/jats:italic> (<jats:italic>p<\/jats:italic> &lt; 0.05). The detection rate of vancomycin\u2010resistant<jats:italic>Enterococcus faecium<\/jats:italic> and <jats:italic>Enterococcus faecalis<\/jats:italic> was 37.3% and 3.1%, respectively, and the detection rate of linezolid\u2010resistant<jats:italic>Enterococcus faecium<\/jats:italic> and <jats:italic>Enterococcus faecalis<\/jats:italic> was 0.68% and 0%, respectively. The drug resistance rate of <jats:italic>candida<\/jats:italic> sp<jats:italic>.<\/jats:italic> to fluconazole, itraconazole, and voriconazole was 1.7%, 8.5%, and 3.4%, respectively. No amphotericin B\u2010resistant strains were detected in the research. <jats:italic>Conclusions<\/jats:italic>. Among the 5669 strains isolated from urinary tract infection patients, GNB were the main pathogens. <jats:italic>Escherichia coli<\/jats:italic> was the major pathogen. The resistance rate of ESBLs\u2010producing<jats:italic>Escherichia coli<\/jats:italic> was higher than that of non\u2010ESBLs\u2010producing<jats:italic>Escherichia coli<\/jats:italic> in general; meanwhile, <jats:italic>\u03b2<\/jats:italic>\u2010lactam\/<jats:italic>\u03b2<\/jats:italic>\u2010lactamase inhibitors and carbapenems maintained good antimicrobial activity against <jats:italic>Escherichia coli<\/jats:italic>. The resistance rate of non\u2010ESBLs\u2010producing<jats:italic>Klebsiella pneumoniae<\/jats:italic> strains was significantly higher than that of ESBLs\u2010producing<jats:italic>Klebsiella pneumoniae<\/jats:italic> strains, and drug resistance was more prominent; most of the antibiotic resistance rates were over 50%. The antimicrobial resistance rate of <jats:italic>Enterococcus faecium<\/jats:italic> was significantly higher than that of <jats:italic>Enterococcus faecalis<\/jats:italic>. There were rare linezolid\u2010resistant strains. The antimicrobial resistance rate of imidazole to fungi was controlled less than 10%.<\/jats:p>","DOI":"10.1155\/2023\/4360342","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T16:50:07Z","timestamp":1690217407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of Antimicrobial Susceptibility in Bacterial Pathogens Associated with Urinary Tract Infections from Beijing Teaching Hospital in China, 2009\u20132017"],"prefix":"10.1155","volume":"2023","author":[{"given":"Zeqiang","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyong","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2476-1440","authenticated-orcid":false,"given":"Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"1","article-title":"Bacterial pathogens implicated in causing urinary tract infection (uti) and their antimicrobial susceptibility pattern in Ethiopia","volume":"41","author":"Getachew T.","year":"2010","journal-title":"Revista CENIC Ciencias Biologicas"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3432"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(05)83481-x"},{"key":"e_1_2_10_4_2","first-page":"445","article-title":"The microbial agents of urinary tract infections at central laboratory of Dr. Shariati Hospital","volume":"28","author":"Behzadi P.","year":"2008","journal-title":"Turk Klin Tip Bilim"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2021.100881"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.11-3-300"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2015.01.474"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825999190619130216"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1135614"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9102104"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9112384"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11111514"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/329541"},{"key":"e_1_2_10_14_2","doi-asserted-by":"crossref","unstructured":"BehzadiP.andBehzadiE. 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